biostudies-literatureLakin HAOregon State UniversityMorris Animal FoundationNational Science Foundatione0010906https://www.ebi.ac.uk/biostudies/studies/S-EPMC9683594biostudies-literatureUnknown16(11)<h4>Background</h4>Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a model for the study of human tuberculosis, more closely resembling the localization and progression of lesions in controlled studies than murine models. If disease in African buffalo progresses similarly to experimentally infected cattle, they may serve as a model, both for human tuberculosis and cattle BTB, in a natural environment.<h4>Methodology/principal findings</h4>We utilized a herd of African buffalo that were captured, fitted with radio collars, and tested for BTB twice annually dPLoS neglected tropical diseasesBovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection.PMC9683594EF-0723918/DEB-1102493, EF-0723928D15ZO-824Budischak SAMiller MJolles AEzenwa VOBuss PTavalire HSakamoto KLakin HARaum KBeechler BfalseBovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection.<h4>Background</h4>Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a model for the study of human tuberculosis, more closely resembling the localization and progression of lesions in controlled studies than murine models. If disease in African buffalo progresses similarly to experimentally infected cattle, they may serve as a model, both for human tuberculosis and cattle BTB, in a natural environment.<h4>Methodology/principal findings</h4>We utilized a herd of African buffalo that were captured, fitted with radio collars, and tested for BTB twice annually d2022-01-01T00:00:00Z2022 Nov2025-04-25T21:03:12.77Z2025-04-06T08:37:38.688ZS-EPMC96835943636787210.1371/journal.pntd.0010906