{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lamri A"],"funding":["Economic and Social Research Council","Heart and Stroke Foundation","British Heart Foundation","Bristol NIHR Biomedical Research Center","Medical Research Council","Wellcome Trust","Canadian Institutes of Health Research","CIHR","Canada Research Chairs"],"pagination":["e81498"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9683781"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["South Asian women are at increased risk of developing gestational diabetes mellitus (GDM). Few studies have investigated the genetic contributions to GDM risk. We investigated the association of a type 2 diabetes (T2D) polygenic risk score (PRS), on its own, and with GDM risk factors, on GDM-related traits using data from two birth cohorts in which South Asian women were enrolled during pregnancy. 837 and 4372 pregnant South Asian women from the SouTh Asian BiRth CohorT (START) and Born in Bradford (BiB) cohort studies underwent a 75-g glucose tolerance test. PRSs were derived using genome-wide association study results from an independent multi-ethnic study (~18% South Asians). Associations with fasting plasma glucose (FPG); 2 hr post-load glucose (2hG); area under the curve glucose; and "],"journal":["eLife"],"pubmed_title":["The genetic risk of gestational diabetes in South Asian women."],"pmcid":["PMC9683781"],"funding_grant_id":["WT101597MA","FDN-143255","CH/F/20/90003","Project grant 298104;Foundation grant number: FDN-143255","CS/16/4/32482","298104","Michael G. DeGroote Chair","MC_UU_00011/6","MR/N024397/1"],"pubmed_authors":["Kelly B","Schulze KM","Pare G","Lawlor DA","On Behalf Of For The Born In Bradford And Start Investigators","Lamri A","for the Born in Bradford and START investigators","Limbachia J","de Souza RJ","Wright J","Desai D","Anand SS"],"additional_accession":[]},"is_claimable":false,"name":"The genetic risk of gestational diabetes in South Asian women.","description":"South Asian women are at increased risk of developing gestational diabetes mellitus (GDM). Few studies have investigated the genetic contributions to GDM risk. We investigated the association of a type 2 diabetes (T2D) polygenic risk score (PRS), on its own, and with GDM risk factors, on GDM-related traits using data from two birth cohorts in which South Asian women were enrolled during pregnancy. 837 and 4372 pregnant South Asian women from the SouTh Asian BiRth CohorT (START) and Born in Bradford (BiB) cohort studies underwent a 75-g glucose tolerance test. PRSs were derived using genome-wide association study results from an independent multi-ethnic study (~18% South Asians). Associations with fasting plasma glucose (FPG); 2 hr post-load glucose (2hG); area under the curve glucose; and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-05T10:57:39.824Z","creation":"2025-04-05T10:57:39.824Z"},"accession":"S-EPMC9683781","cross_references":{"pubmed":["36412575"],"doi":["10.7554/eLife.81498"]}}