{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Zeng Y"],"pubmed_abstract":["Subarachnoid hemorrhage (SAH) as a devastating neurological disorder is closely related to heightened oxidative insults and neuroinflammatory injury. Pinocembrin, a bioflavonoid, exhibits different biological functions, such as immunomodulatory, anti-inflammatory, antioxidative, and cerebroprotective activities. Herein, we examined the protective effects and molecular mechanisms of pinocembrin in a murine model of SAH. Using an endovascular perforation model in rats, pinocembrin significantly mitigated SAH-induced neuronal tissue damage, including inflammatory injury and free-radical insults. Meanwhile, pinocembrin improved behavior function and reduced neuronal apoptosis. We also revealed that sirtuin-1 (SIRT1) activation was significantly enhanced by pinocembrin. In addition, pinocembrin"],"journal":["Oxidative medicine and cellular longevity"],"pagination":["2242833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9683949"],"repository":["biostudies-literature"],"pubmed_title":["Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage."],"pmcid":["PMC9683949"],"pubmed_authors":["Wu Z","Lai J","Fang Z","Chen J","Hu W","Guo X","Lin W","Zeng Y","Chen X","Yao H"],"additional_accession":[]},"is_claimable":false,"name":"Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage.","description":"Subarachnoid hemorrhage (SAH) as a devastating neurological disorder is closely related to heightened oxidative insults and neuroinflammatory injury. Pinocembrin, a bioflavonoid, exhibits different biological functions, such as immunomodulatory, anti-inflammatory, antioxidative, and cerebroprotective activities. Herein, we examined the protective effects and molecular mechanisms of pinocembrin in a murine model of SAH. Using an endovascular perforation model in rats, pinocembrin significantly mitigated SAH-induced neuronal tissue damage, including inflammatory injury and free-radical insults. Meanwhile, pinocembrin improved behavior function and reduced neuronal apoptosis. We also revealed that sirtuin-1 (SIRT1) activation was significantly enhanced by pinocembrin. In addition, pinocembrin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:51:19.903Z","creation":"2025-04-04T19:51:19.903Z"},"accession":"S-EPMC9683949","cross_references":{"pubmed":["36439686"],"doi":["10.1155/2022/2242833"]}}