{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiao Z"],"funding":["Beijing Outstanding Young Scientist Program","National Natural Science Foundation of China"],"pagination":["7164"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9684156"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Nanotechnology enlightens promising antibacterial strategies while the complex in vivo infection environment poses a great challenge to the rational design of nanoplatforms for safe and effective anti-infective therapy. Herein, a biomimetic nanoplatform (EV-Pd-Pt) integrating electrodynamic Pd-Pt nanosheets and natural ginger-derived extracellular vesicles (EVs) is proposed. The introduction of ginger-derived EVs greatly endows EV-Pd-Pt with prolonged blood circulation without immune clearance, as well as accumulation at infection sites. More interestingly, EV-Pd-Pt can enter the interior of bacteria in an EV lipid-dependent manner. At the same time, reactive oxygen species are sustainably generated in situ to overcome the limitations of their short lifetime and diffusion distance. Notably"],"journal":["Nature communications"],"pubmed_title":["Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy."],"pmcid":["PMC9684156"],"funding_grant_id":["52173271 and 51922022"],"pubmed_authors":["Cheng D","Zhao N","Liu J","Zhang K","Yu B","Xu FJ","Qiao Z"],"additional_accession":[]},"is_claimable":false,"name":"Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy.","description":"Nanotechnology enlightens promising antibacterial strategies while the complex in vivo infection environment poses a great challenge to the rational design of nanoplatforms for safe and effective anti-infective therapy. Herein, a biomimetic nanoplatform (EV-Pd-Pt) integrating electrodynamic Pd-Pt nanosheets and natural ginger-derived extracellular vesicles (EVs) is proposed. The introduction of ginger-derived EVs greatly endows EV-Pd-Pt with prolonged blood circulation without immune clearance, as well as accumulation at infection sites. More interestingly, EV-Pd-Pt can enter the interior of bacteria in an EV lipid-dependent manner. At the same time, reactive oxygen species are sustainably generated in situ to overcome the limitations of their short lifetime and diffusion distance. Notably","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-07-13T03:04:15.261Z","creation":"2025-04-19T04:20:24.75Z"},"accession":"S-EPMC9684156","cross_references":{"pubmed":["36418895"],"doi":["10.1038/s41467-022-34883-5"]}}