biostudies-literaturePeetermans MFonds Wetenschappelijk Onderzoek37-49https://www.ebi.ac.uk/biostudies/studies/S-EPMC9684759biostudies-literatureUnknown49(1)<h4>Purpose</h4>The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults with class II obesity or more (BMI ≥ 35 kg/m²) have worse outcomes than lean counterparts, (ii) the form of the relationship between BMI and outcomes, (iii) whether a cutoff marking futility can be identified.<h4>Methods</h4>A retrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry from 1/1/2010 to 31/12/2020 was conducted. Impact of BMI ≥ 35 kg/m² was assessed with propensity-score (PS) matching, inverse propensity-score weighted (IPSW) and multivariable models (MV), adjusting for a priori identified confounders. Primary outcome wIntensive care medicineImpact of BMI on outcomes in respiratory ECMO: an ELSO registry study.PMC96847591805121NHermans GVlaar APJWauters JPeetermans MGuler ICombes AMeersseman PWilmer AMeyns BfalseImpact of BMI on outcomes in respiratory ECMO: an ELSO registry study.<h4>Purpose</h4>The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults with class II obesity or more (BMI ≥ 35 kg/m²) have worse outcomes than lean counterparts, (ii) the form of the relationship between BMI and outcomes, (iii) whether a cutoff marking futility can be identified.<h4>Methods</h4>A retrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry from 1/1/2010 to 31/12/2020 was conducted. Impact of BMI ≥ 35 kg/m² was assessed with propensity-score (PS) matching, inverse propensity-score weighted (IPSW) and multivariable models (MV), adjusting for a priori identified confounders. Primary outcome w2023-01-01T00:00:00Z2023 Jan2025-04-25T19:58:54.007Z2025-02-19T01:55:38.383ZS-EPMC96847593641689610.1007/s00134-022-06926-4