{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(1)"],"submitter":["Simplicien M"],"pubmed_abstract":["The S protein forming the homotrimeric spikes of pathogenic beta-coronaviruses, such as MERS-CoV, SARS-CoV and SARS-CoV-2, is a highly glycosylated protein containing mainly N-glycans of the complex and high-mannose type, as well as O-glycans. Similarly, the host cell receptors DPP4 for MERS-CoV and ACE2 for SARS-CoV and SARS-CoV-2, also represent N- and O-glycosylated proteins. All these glycoproteins share common glycosylation patterns, suggesting that plant lectins with different carbohydrate-binding specificities could be used as carbohydrate-binding agents for the spikes and their receptors, to combat COVID19 pandemics. The binding of plant lectins to the spikes and their receptors could mask the non-glycosylated receptor binding domain of the virus and the corresponding region of the"],"journal":["Glycoconjugate journal"],"pagination":["109-118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9684959"],"repository":["biostudies-literature"],"pubmed_title":["Plant lectins as versatile tools to fight coronavirus outbreaks."],"pmcid":["PMC9684959"],"pubmed_authors":["Perio P","Barre A","Simplicien M","Sudor J","Benoist H","Van Damme EJM","Rouge P"],"additional_accession":[]},"is_claimable":false,"name":"Plant lectins as versatile tools to fight coronavirus outbreaks.","description":"The S protein forming the homotrimeric spikes of pathogenic beta-coronaviruses, such as MERS-CoV, SARS-CoV and SARS-CoV-2, is a highly glycosylated protein containing mainly N-glycans of the complex and high-mannose type, as well as O-glycans. Similarly, the host cell receptors DPP4 for MERS-CoV and ACE2 for SARS-CoV and SARS-CoV-2, also represent N- and O-glycosylated proteins. All these glycoproteins share common glycosylation patterns, suggesting that plant lectins with different carbohydrate-binding specificities could be used as carbohydrate-binding agents for the spikes and their receptors, to combat COVID19 pandemics. The binding of plant lectins to the spikes and their receptors could mask the non-glycosylated receptor binding domain of the virus and the corresponding region of the","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-19T22:46:58.445Z","creation":"2025-04-19T22:46:58.445Z"},"accession":"S-EPMC9684959","cross_references":{"pubmed":["36418811"],"doi":["10.1007/s10719-022-10094-4"]}}