{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["49(1)"],"submitter":["Bontemps I"],"pubmed_abstract":["Cancer stem cells (CSCs) serve an essential role in failure of conventional antitumor therapy. In breast cancer, CD24<sup>‑/low</sup>/CD44<sup>+</sup> phenotype and high aldehyde dehydrogenase activity are associated with CSC subtypes. Furthermore, CD24<sup>‑/low</sup>/CD44<sup>+</sup> pattern is also characteristic of mesenchymal cells generated by epithelial‑mesenchymal transition (EMT). CD24 is a surface marker expressed in numerous types of tumor, however, its biological functions and role in cancer progression and treatment resistance remain poorly documented. Loss of CD24 expression in breast cancer cells is associated with radiation resistance and control of oxidative stress. Reactive oxygen species (ROS) mediate the effects of anticancer drugs as well as ionizing radiation; therefo"],"journal":["Oncology reports"],"pagination":["4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9685273"],"repository":["biostudies-literature"],"pubmed_title":["Loss of CD24 promotes radiation‑ and chemo‑resistance by inducing stemness properties associated with a hybrid E/M state in breast cancer cells."],"pmcid":["PMC9685273"],"pubmed_authors":["Boussin F","Bourneuf E","Biard D","Siberchicot C","Bontemps I","Lallemand C","Dechamps N","Kortulewski T","Chevillard S","Campalans A","Lebeau J"],"additional_accession":[]},"is_claimable":false,"name":"Loss of CD24 promotes radiation‑ and chemo‑resistance by inducing stemness properties associated with a hybrid E/M state in breast cancer cells.","description":"Cancer stem cells (CSCs) serve an essential role in failure of conventional antitumor therapy. In breast cancer, CD24<sup>‑/low</sup>/CD44<sup>+</sup> phenotype and high aldehyde dehydrogenase activity are associated with CSC subtypes. Furthermore, CD24<sup>‑/low</sup>/CD44<sup>+</sup> pattern is also characteristic of mesenchymal cells generated by epithelial‑mesenchymal transition (EMT). CD24 is a surface marker expressed in numerous types of tumor, however, its biological functions and role in cancer progression and treatment resistance remain poorly documented. Loss of CD24 expression in breast cancer cells is associated with radiation resistance and control of oxidative stress. Reactive oxygen species (ROS) mediate the effects of anticancer drugs as well as ionizing radiation; therefo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-05T15:22:04.789Z","creation":"2025-04-05T15:22:04.789Z"},"accession":"S-EPMC9685273","cross_references":{"pubmed":["36367190"],"doi":["10.3892/or.2022.8441"]}}