{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(46)"],"submitter":["Yıldırım H"],"pubmed_abstract":["Our previous studies have revealed that the aminated 1,4-quinone scaffold can be used for the development of novel antibacterial and/or antifungal agents. In this study, the aminated quinolinequinones (<b>AQQ1-9</b>) were designed, synthesized, and evaluated for their antimicrobial activity against a panel of seven bacterial strains (three Gram-positive and four Gram-negative bacteria) and three fungal strains. The structure-activity relationship (SAR) for the QQs was also summarized. The antibacterial activity results indicated that the two aminated QQs (<b>AQQ6</b> and <b>AQQ9</b>) were active against <i>Enterococcus faecalis</i> (ATCC 29212) with a MIC value of 78.12 μg/mL. Besides, the two aminated QQs (<b>AQQ8</b> and <b>AQQ9</b>) were active against <i>Staphylococcus aureus</i> (ATCC"],"journal":["ACS omega"],"pagination":["41915-41928"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9685608"],"repository":["biostudies-literature"],"pubmed_title":["Aminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, <i>In Vitro</i> Evaluation, and Putative Mode of Action."],"pmcid":["PMC9685608"],"pubmed_authors":["Yıldırım H","Jayaprakash V","Korkmaz S","Mataracı-Kara E","Bayrak N","Yıldız M","TuYuN AF","Shilkar D"],"additional_accession":[]},"is_claimable":false,"name":"Aminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, <i>In Vitro</i> Evaluation, and Putative Mode of Action.","description":"Our previous studies have revealed that the aminated 1,4-quinone scaffold can be used for the development of novel antibacterial and/or antifungal agents. In this study, the aminated quinolinequinones (<b>AQQ1-9</b>) were designed, synthesized, and evaluated for their antimicrobial activity against a panel of seven bacterial strains (three Gram-positive and four Gram-negative bacteria) and three fungal strains. The structure-activity relationship (SAR) for the QQs was also summarized. The antibacterial activity results indicated that the two aminated QQs (<b>AQQ6</b> and <b>AQQ9</b>) were active against <i>Enterococcus faecalis</i> (ATCC 29212) with a MIC value of 78.12 μg/mL. Besides, the two aminated QQs (<b>AQQ8</b> and <b>AQQ9</b>) were active against <i>Staphylococcus aureus</i> (ATCC","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T19:51:38.495Z","creation":"2025-04-04T19:51:38.495Z"},"accession":"S-EPMC9685608","cross_references":{"pubmed":["36440112"],"doi":["10.1021/acsomega.2c03193"]}}