biostudies-literatureUnknown7(46)Yıldırım HOur previous studies have revealed that the aminated 1,4-quinone scaffold can be used for the development of novel antibacterial and/or antifungal agents. In this study, the aminated quinolinequinones (<b>AQQ1-9</b>) were designed, synthesized, and evaluated for their antimicrobial activity against a panel of seven bacterial strains (three Gram-positive and four Gram-negative bacteria) and three fungal strains. The structure-activity relationship (SAR) for the QQs was also summarized. The antibacterial activity results indicated that the two aminated QQs (<b>AQQ6</b> and <b>AQQ9</b>) were active against <i>Enterococcus faecalis</i> (ATCC 29212) with a MIC value of 78.12 μg/mL. Besides, the two aminated QQs (<b>AQQ8</b> and <b>AQQ9</b>) were active against <i>Staphylococcus aureus</i> (ATCCACS omega41915-41928https://www.ebi.ac.uk/biostudies/studies/S-EPMC9685608biostudies-literatureAminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, <i>In Vitro</i> Evaluation, and Putative Mode of Action.PMC9685608Yıldırım HJayaprakash VKorkmaz SMataracı-Kara EBayrak NYıldız MTuYuN AFShilkar DfalseAminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, <i>In Vitro</i> Evaluation, and Putative Mode of Action.Our previous studies have revealed that the aminated 1,4-quinone scaffold can be used for the development of novel antibacterial and/or antifungal agents. In this study, the aminated quinolinequinones (<b>AQQ1-9</b>) were designed, synthesized, and evaluated for their antimicrobial activity against a panel of seven bacterial strains (three Gram-positive and four Gram-negative bacteria) and three fungal strains. The structure-activity relationship (SAR) for the QQs was also summarized. The antibacterial activity results indicated that the two aminated QQs (<b>AQQ6</b> and <b>AQQ9</b>) were active against <i>Enterococcus faecalis</i> (ATCC 29212) with a MIC value of 78.12 μg/mL. Besides, the two aminated QQs (<b>AQQ8</b> and <b>AQQ9</b>) were active against <i>Staphylococcus aureus</i> (ATCC2022-01-01T00:00:00Z2022 Nov2025-04-04T19:51:38.495Z2025-04-04T19:51:38.495ZS-EPMC96856083644011210.1021/acsomega.2c03193