biostudies-literatureUnknown7(46)Packirisamy VA facile synthesis of glutathione-stabilized copper nanoclusters (CuNCs) is carried out in H₂O/ tetrahydrofuran medium. The photophysical and morphological studies performed with as-synthesized CuNCs revealed the formation of green-emissive, stable, and smaller nanoclusters. The precise composition of these as-synthesized CuNCs was predicted with the aid of electrospray ionization mass spectrometry analysis as Cu₁₂(SG)₉. Furthermore, the systematic studies of the interaction of synthesized CuNCs with three plasmatic proteins, namely, bovine serum albumin (BSA), lysozyme (Lys), and hemoglobin (Hb) have been performed by using a series of spectroscopic studies. The conformational changes in these proteins upon interacting with CuNCs and their binding stoichioACS omega42550-42559https://www.ebi.ac.uk/biostudies/studies/S-EPMC9685744biostudies-literatureInteraction of Atomically Precise Thiolated Copper Nanoclusters with Proteins: A Comparative Study.PMC9685744Packirisamy VPandurangan PfalseInteraction of Atomically Precise Thiolated Copper Nanoclusters with Proteins: A Comparative Study.A facile synthesis of glutathione-stabilized copper nanoclusters (CuNCs) is carried out in H₂O/ tetrahydrofuran medium. The photophysical and morphological studies performed with as-synthesized CuNCs revealed the formation of green-emissive, stable, and smaller nanoclusters. The precise composition of these as-synthesized CuNCs was predicted with the aid of electrospray ionization mass spectrometry analysis as Cu₁₂(SG)₉. Furthermore, the systematic studies of the interaction of synthesized CuNCs with three plasmatic proteins, namely, bovine serum albumin (BSA), lysozyme (Lys), and hemoglobin (Hb) have been performed by using a series of spectroscopic studies. The conformational changes in these proteins upon interacting with CuNCs and their binding stoichio2022-01-01T00:00:00Z2022 Nov2025-04-04T19:51:11.335Z2025-04-04T19:51:11.335ZS-EPMC96857443644010510.1021/acsomega.2c06011