{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Niu M"],"funding":["Medical Scientific Research Foundation of Hebei Province","Talent Engineering Training Funding Project of Hebei Province"],"pagination":["482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9685975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Previous studies have reported that the tumor heterogeneity and complex oncogenic mechanisms of proximal and distal colon cancer (CRC) are divergent. Therefore, we aim to analyze the differences between left-sided CRC (L_cancer) and right-sided CRC (R_cancer), as well as constructing respective nomograms.<h4>Methods</h4>We enrolled 335 colon cancer patients (146 L_cancer patients and 189 R_cancer patients) from The Cancer Genome Atlas (TCGA) data sets, and 102 pairs of color cancer tissue and adjacent normal tissue (51 L_cancer patients and 51 R_cancer patients) from our hospital. Firstly, we analyzed the differences between the L_cancer patients and R_cancer patients, and then established the L_cancer and R_cancer prognostic models using LASSO Cox.<h4>Results</h4>R_canc"],"journal":["BMC gastroenterology"],"pubmed_title":["Comprehensive analysis of the differences between left- and right-side colorectal cancer and respective prognostic prediction."],"pmcid":["PMC9685975"],"funding_grant_id":["LS202001","H2020206374"],"pubmed_authors":["Guo Y","Chen C","Li L","Zhao Z","Niu X","Li Z","Jiang X","Niu M","Gao X","Wang X","Chen S","Zhang C","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of the differences between left- and right-side colorectal cancer and respective prognostic prediction.","description":"<h4>Background</h4>Previous studies have reported that the tumor heterogeneity and complex oncogenic mechanisms of proximal and distal colon cancer (CRC) are divergent. Therefore, we aim to analyze the differences between left-sided CRC (L_cancer) and right-sided CRC (R_cancer), as well as constructing respective nomograms.<h4>Methods</h4>We enrolled 335 colon cancer patients (146 L_cancer patients and 189 R_cancer patients) from The Cancer Genome Atlas (TCGA) data sets, and 102 pairs of color cancer tissue and adjacent normal tissue (51 L_cancer patients and 51 R_cancer patients) from our hospital. Firstly, we analyzed the differences between the L_cancer patients and R_cancer patients, and then established the L_cancer and R_cancer prognostic models using LASSO Cox.<h4>Results</h4>R_canc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T14:44:20.456Z","creation":"2025-04-19T14:44:20.456Z"},"accession":"S-EPMC9685975","cross_references":{"pubmed":["36419007"],"doi":["10.1186/s12876-022-02585-3"]}}