{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Fraternale D"],"pubmed_abstract":["In the present study, <i>Monarda didyma</i> L. essential oil (isolated from the flowering aerial parts of the plant) was examined to characterize its chemotype and to evaluate, in addition to the quali-quantitative chemical analysis, the associated antioxidant and anti-inflammatory activities. The plants were grown in central Italy, Urbino (PU), Marche region. Different analyses (TLC, GC-FID, GC-MS and <sup>1</sup>H-NMR) allowed the identification of twenty compounds among which carvacrol, p-cymene and thymol were the most abundant. On this basis, the chemotype examined in the present study was indicated as <i>Monarda didyma</i> ct. carvacrol. The antioxidant effect was assessed by DPPH assay. Moreover, this chemotype was investigated for the anti-inflammatory effect in an <i>in vitro</i> setting (<i>i.e</i>., LPS-stimulated U937 cells). The decreased expression of pro-inflammatory cytokine IL-6 and the increased expression of miR-146a are suggestive of the involvement of the Toll-like receptor-4 signaling pathway. Although further studies are needed to better investigate the action mechanism/s underlying the results observed in the experimental setting, our findings show that <i>M. didyma</i> essential oil is rich in bioactive compounds (mainly aromatic monoterpenes and phenolic monoterpenes) which are most likely responsible for its beneficial effect."],"journal":["PeerJ"],"pagination":["e14433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686412"],"repository":["biostudies-literature"],"pubmed_title":["Chemical composition, antioxidant and anti-inflammatory properties of <i>Monarda didyma</i> L. essential oil."],"pmcid":["PMC9686412"],"pubmed_authors":["Fraternale D","Melandri D","Albertini MC","D'Adderio R","Dufat H","Bouzidi C","Di Giacomo B","Ramakrishna S","Colomba M","Coppari S"],"additional_accession":[]},"is_claimable":false,"name":"Chemical composition, antioxidant and anti-inflammatory properties of <i>Monarda didyma</i> L. essential oil.","description":"In the present study, <i>Monarda didyma</i> L. essential oil (isolated from the flowering aerial parts of the plant) was examined to characterize its chemotype and to evaluate, in addition to the quali-quantitative chemical analysis, the associated antioxidant and anti-inflammatory activities. The plants were grown in central Italy, Urbino (PU), Marche region. Different analyses (TLC, GC-FID, GC-MS and <sup>1</sup>H-NMR) allowed the identification of twenty compounds among which carvacrol, p-cymene and thymol were the most abundant. On this basis, the chemotype examined in the present study was indicated as <i>Monarda didyma</i> ct. carvacrol. The antioxidant effect was assessed by DPPH assay. Moreover, this chemotype was investigated for the anti-inflammatory effect in an <i>in vitro</i> setting (<i>i.e</i>., LPS-stimulated U937 cells). The decreased expression of pro-inflammatory cytokine IL-6 and the increased expression of miR-146a are suggestive of the involvement of the Toll-like receptor-4 signaling pathway. Although further studies are needed to better investigate the action mechanism/s underlying the results observed in the experimental setting, our findings show that <i>M. didyma</i> essential oil is rich in bioactive compounds (mainly aromatic monoterpenes and phenolic monoterpenes) which are most likely responsible for its beneficial effect.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:51:12.593Z","creation":"2025-04-04T19:51:12.593Z"},"accession":"S-EPMC9686412","cross_references":{"pubmed":["36438580"],"doi":["10.7717/peerj.14433"]}}