biostudies-literatureGomori KJános Bolyai Re-search Fellowship of the Hungarian Academy of SciencesHungarian National Scientific Research FundNRDI FundEMBO short-term fellowshipNew National Excellence ProgramEu-ropean HCEMMEU's Horizon 2020Thematic Excellence ProgrammeDFG (Deutsche Forschungsgemeinschaft)Hungarian National Cardiovascular Laboratory2210https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686542biostudies-literatureUnknown11(11)Volume-induced hypertrophy is one of the risk factors for cardiac morbidity and mortality. In addition, mechanical and metabolic dysfunction, aging, and cellular redox balance are also contributing factors to the disease progression. In this study, we used volume overload (VO), which was induced by an aortocaval fistula in 2-month-old male Wistar rats, and sham-operated animals served as control. Functional parameters were measured by transthoracic echocardiography at termination 4- or 8-months after VO. The animals showed hypertrophic remodeling that was accompanied by mechanical dysfunction and increased cardiomyocyte stiffness. These alterations were reversible upon treatment with glutathione. Cardiomyocyte dysfunction was associated with elevated oxidative stress markers with unchangedAntioxidants (Basel, Switzerland)Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy.PMC96865428792OTKA-138223, K139237HU263073832019-1.1.1-PIACI-KFI-2019-00367HA 7512/2-4 and HA 7512/2-1UNKP-21-5-SZTE-543No. 739593RRF-2.3.1-21-2022-000032020-4.1.1.-TKP2020bo_481_21Ferdinandy PFarkas-Morvay NBegovic MBudde HModi SKovacs AHassoun RPipis JLepran IMostafi NBencsik PGomori KDelalat SGorbe AMugge AHerwig MHamdani NSzabados TfalseAltered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy.Volume-induced hypertrophy is one of the risk factors for cardiac morbidity and mortality. In addition, mechanical and metabolic dysfunction, aging, and cellular redox balance are also contributing factors to the disease progression. In this study, we used volume overload (VO), which was induced by an aortocaval fistula in 2-month-old male Wistar rats, and sham-operated animals served as control. Functional parameters were measured by transthoracic echocardiography at termination 4- or 8-months after VO. The animals showed hypertrophic remodeling that was accompanied by mechanical dysfunction and increased cardiomyocyte stiffness. These alterations were reversible upon treatment with glutathione. Cardiomyocyte dysfunction was associated with elevated oxidative stress markers with unchanged2022-01-01T00:00:00Z2022 Nov2025-04-19T16:13:21.383Z2025-04-19T16:13:21.383ZS-EPMC96865423635858110.3390/antiox11112210