biostudies-literatureAlcaraz MThis research was funded by the National Spanish R&amp;D Programme CENIT of the Spanish Min-istry of Science and Technology named "Industrial Research and Experimental Development of Intelligent Foods (Acronym: SMARTFOODS).National Spanish R&amp;D Programme CENIT of the Spanish Ministry of Science and Technology “Industrial Research and Experimental Development of Intelligent Foods”2166https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686564biostudies-literatureUnknown11(11)Carnosic acid (CA) is a phenolic diterpene characterized by its high antioxidant activity; it is used in industrial, cosmetic, and nutritional applications. We evaluated the radioprotective capacity of CA on cells directly exposed to X-rays and non-irradiated cells that received signals from X-ray treated cells (radiation induced bystander effect, RIBE). The genoprotective capacity was studied by in vivo and in vitro micronucleus assays. Radioprotective capacity was evaluated by clonogenic cell survival, MTT, apoptosis and intracellular glutathione assays comparing radiosensitive cells (human prostate epithelium, PNT2) with radioresistant cells (murine metastatic melanoma, B16F10). CA was found to exhibit a genoprotective capacity in cells exposed to radiation (p < 0.001) and in RIBE (p < Antioxidants (Basel, Switzerland)Paradoxical Radiosensitizing Effect of Carnosic Acid on B16F10 Metastatic Melanoma Cells: A New Treatment Strategy.PMC9686564SMARTFOODSAndreu-Galvez MOlivares AMercado AMAchel DGAlcaraz-Saura MAlcaraz MfalseParadoxical Radiosensitizing Effect of Carnosic Acid on B16F10 Metastatic Melanoma Cells: A New Treatment Strategy.Carnosic acid (CA) is a phenolic diterpene characterized by its high antioxidant activity; it is used in industrial, cosmetic, and nutritional applications. We evaluated the radioprotective capacity of CA on cells directly exposed to X-rays and non-irradiated cells that received signals from X-ray treated cells (radiation induced bystander effect, RIBE). The genoprotective capacity was studied by in vivo and in vitro micronucleus assays. Radioprotective capacity was evaluated by clonogenic cell survival, MTT, apoptosis and intracellular glutathione assays comparing radiosensitive cells (human prostate epithelium, PNT2) with radioresistant cells (murine metastatic melanoma, B16F10). CA was found to exhibit a genoprotective capacity in cells exposed to radiation (p < 0.001) and in RIBE (p < 2022-01-01T00:00:00Z2022 Oct2025-04-04T22:35:30.376Z2025-04-04T22:35:30.376ZS-EPMC96865643635853910.3390/antiox11112166