{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun C"],"funding":["Guizhou Provincial Natural Science Foundation","National Natural Science Foundation of China","Science and Technology Planning Project of Guizhou Province"],"pagination":["1474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["The biofilm formation of <i>C. albicans</i> represents a major virulence factor during candidiasis. Biofilm-mediated drug resistance has necessitated the search for a new antifungal treatment strategy. In our previous study, a novel antimicrobial peptide named AMP-17 derived from <i>Musca domestica</i> was confirmed to have significant antifungal activity and suppress hyphal growth greatly in <i>C. albicans</i>. In the current work, we aimed to investigate the antibiofilm property of AMP-17 in <i>C. albicans</i> and explore the underlying mechanism. An antifungal susceptibility assay showed that AMP-17 exerted a strong inhibitory efficacy on both biofilm formation and preformed biofilms in <i>C. albicans</i>. Furthermore, AMP-17 was found to block the yeast-to-hypha transition and inhibit "],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["The Antimicrobial Peptide AMP-17 Derived from <i>Musca domestica</i> Inhibits Biofilm Formation and Eradicates Mature Biofilm in <i>Candida albicans</i>."],"pmcid":["PMC9686669"],"funding_grant_id":["ZK[2022] general project 345","(ZK[2022] Key Program 039)","82002180","82060381"],"pubmed_authors":["Zhou L","Yang L","Sun C","Guo G","Huang M","Tian C","Jiao Z","Peng J","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"The Antimicrobial Peptide AMP-17 Derived from <i>Musca domestica</i> Inhibits Biofilm Formation and Eradicates Mature Biofilm in <i>Candida albicans</i>.","description":"The biofilm formation of <i>C. albicans</i> represents a major virulence factor during candidiasis. Biofilm-mediated drug resistance has necessitated the search for a new antifungal treatment strategy. In our previous study, a novel antimicrobial peptide named AMP-17 derived from <i>Musca domestica</i> was confirmed to have significant antifungal activity and suppress hyphal growth greatly in <i>C. albicans</i>. In the current work, we aimed to investigate the antibiofilm property of AMP-17 in <i>C. albicans</i> and explore the underlying mechanism. An antifungal susceptibility assay showed that AMP-17 exerted a strong inhibitory efficacy on both biofilm formation and preformed biofilms in <i>C. albicans</i>. Furthermore, AMP-17 was found to block the yeast-to-hypha transition and inhibit ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T17:08:07.131Z","creation":"2025-04-07T04:43:26.117Z"},"accession":"S-EPMC9686669","cross_references":{"pubmed":["36358129"],"doi":["10.3390/antibiotics11111474"]}}