{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ullah MI"],"funding":["This research was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia,"],"pagination":["2232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["This study aimed to assess the potential of <i>Lactuca serriola</i> (Asteraceae) seed <i>n</i>-hexane, chloroform, methanol, and aqueous extracts as anticonvulsant, sedative, anticonvulsant and antiepileptic agents in Swiss albino mice. Different doses of each extract were evaluated for the anxiolytic potential using the hole-board, the elevated plus maze and the light/dark test. A phenobarbitone-induced sleep test was employed for the evaluation of sedative potential. Acute anticonvulsant activity was evaluated by picrotoxin and strychnine-induced convulsion models. All extracts significantly reduced the number of head dips where <i>n</i>-hexane extract (400 mg/kg) showed 96.34% reduction in the tendency of head dipping when compared with the control. Mice treated with extracts preferred "],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Evaluation of the Anxiolytic and Anti-Epileptogenic Potential of <i>Lactuca Serriola</i> Seed Using Pentylenetetrazol-Induced Kindling in Mice and Metabolic Profiling of Its Bioactive Extract."],"pmcid":["PMC9686728"],"funding_grant_id":["under grant number (RG-1-166-43)."],"pubmed_authors":["Kamran S","Ullah MI","Anwar R","Youssef FS","Elhady SS","Gul B"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of the Anxiolytic and Anti-Epileptogenic Potential of <i>Lactuca Serriola</i> Seed Using Pentylenetetrazol-Induced Kindling in Mice and Metabolic Profiling of Its Bioactive Extract.","description":"This study aimed to assess the potential of <i>Lactuca serriola</i> (Asteraceae) seed <i>n</i>-hexane, chloroform, methanol, and aqueous extracts as anticonvulsant, sedative, anticonvulsant and antiepileptic agents in Swiss albino mice. Different doses of each extract were evaluated for the anxiolytic potential using the hole-board, the elevated plus maze and the light/dark test. A phenobarbitone-induced sleep test was employed for the evaluation of sedative potential. Acute anticonvulsant activity was evaluated by picrotoxin and strychnine-induced convulsion models. All extracts significantly reduced the number of head dips where <i>n</i>-hexane extract (400 mg/kg) showed 96.34% reduction in the tendency of head dipping when compared with the control. Mice treated with extracts preferred ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-06-01T12:01:33.586Z","creation":"2024-12-04T01:41:03.237Z"},"accession":"S-EPMC9686728","cross_references":{"pubmed":["36421417"],"doi":["10.3390/antiox11112232"]}}