biostudies-literatureUllah MIThis research was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia,2232https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686728biostudies-literatureUnknown11(11)This study aimed to assess the potential of <i>Lactuca serriola</i> (Asteraceae) seed <i>n</i>-hexane, chloroform, methanol, and aqueous extracts as anticonvulsant, sedative, anticonvulsant and antiepileptic agents in Swiss albino mice. Different doses of each extract were evaluated for the anxiolytic potential using the hole-board, the elevated plus maze and the light/dark test. A phenobarbitone-induced sleep test was employed for the evaluation of sedative potential. Acute anticonvulsant activity was evaluated by picrotoxin and strychnine-induced convulsion models. All extracts significantly reduced the number of head dips where <i>n</i>-hexane extract (400 mg/kg) showed 96.34% reduction in the tendency of head dipping when compared with the control. Mice treated with extracts preferred Antioxidants (Basel, Switzerland)Evaluation of the Anxiolytic and Anti-Epileptogenic Potential of <i>Lactuca Serriola</i> Seed Using Pentylenetetrazol-Induced Kindling in Mice and Metabolic Profiling of Its Bioactive Extract.PMC9686728under grant number (RG-1-166-43).Kamran SUllah MIAnwar RYoussef FSElhady SSGul BfalseEvaluation of the Anxiolytic and Anti-Epileptogenic Potential of <i>Lactuca Serriola</i> Seed Using Pentylenetetrazol-Induced Kindling in Mice and Metabolic Profiling of Its Bioactive Extract.This study aimed to assess the potential of <i>Lactuca serriola</i> (Asteraceae) seed <i>n</i>-hexane, chloroform, methanol, and aqueous extracts as anticonvulsant, sedative, anticonvulsant and antiepileptic agents in Swiss albino mice. Different doses of each extract were evaluated for the anxiolytic potential using the hole-board, the elevated plus maze and the light/dark test. A phenobarbitone-induced sleep test was employed for the evaluation of sedative potential. Acute anticonvulsant activity was evaluated by picrotoxin and strychnine-induced convulsion models. All extracts significantly reduced the number of head dips where <i>n</i>-hexane extract (400 mg/kg) showed 96.34% reduction in the tendency of head dipping when compared with the control. Mice treated with extracts preferred 2022-01-01T00:00:00Z2022 Nov2025-06-01T12:01:33.586Z2024-12-04T01:41:03.237ZS-EPMC96867283642141710.3390/antiox11112232