biostudies-literatureDel Castillo-Izquierdo AInstituto de Salud Carlos IIIGirona Biomedical Research InstituteMarie Skłodowska-Curie Innovative Training NetworkFundació Marató de TV3European Regional Development Fund2177https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686780biostudies-literatureUnknown11(11)Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is known to bind nucleic acids with high affinity and directly interact with double stranded RNA, which plays a key role in viral replication. <i>DPP9</i> has also recently emerged as a key gene related to lung-inflammation in critical SARS-CoV-2 infection. Importantly, DPP9 activity is strongly dependent on the oxidative status. Here, we explored the potential role of <i>DPP9</i> in the gastrointestinal tract. We performed transcriptomics analyses of colon (microarray, <i>n</i> = 37) and jejunal (RNA sequencing, <i>n</i> = 31) biopsies from two independent cohorts as well as pAntioxidants (Basel, Switzerland)DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection.PMC9686780201612-31PI20/01090CM19/00190859890CP18/00009Mayneris-Perxachs JLatorre JLefebvre PPuig JBallanti MPamplona RRamos RPortero-Otin MArnoriaga-Rodriguez MMoreno-Navarrete JMStaels BMingrone GAlessandro Paoluzi OFederici MFernandez-Real JMGarre-Olmo JDel Castillo-Izquierdo AJove MMonteleone GSol JfalseDPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection.Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is known to bind nucleic acids with high affinity and directly interact with double stranded RNA, which plays a key role in viral replication. <i>DPP9</i> has also recently emerged as a key gene related to lung-inflammation in critical SARS-CoV-2 infection. Importantly, DPP9 activity is strongly dependent on the oxidative status. Here, we explored the potential role of <i>DPP9</i> in the gastrointestinal tract. We performed transcriptomics analyses of colon (microarray, <i>n</i> = 37) and jejunal (RNA sequencing, <i>n</i> = 31) biopsies from two independent cohorts as well as p2022-01-01T00:00:00Z2022 Nov2026-04-08T11:01:50.224Z2024-11-20T11:17:16.938ZS-EPMC96867803635855110.3390/antiox11112177