biostudies-literatureGallego-Rentero MCantabria labs and Instituto de Salud Carlos III and MINECO and FEDER funds (PI18/00708 and PI21)Instituto de Salud Carlos III MINECO and Feder FundsCantabria Labs2185https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686834biostudies-literatureUnknown11(11)Oxidative stress is a harmful effect induced on the skin by polycyclic aromatic hydrocarbons (PAH), including benzo[a]pyrene (BaP) air pollutants. This effect is amplified by the additive damaging effect of the sun, especially through the UVA light component. Besides being one of the main compounds that make up air pollution, BaP can also be found in tar, tobacco smoke, and various foods. In addition to its direct carcinogenic potential, BaP can act as a photosensitizer absorbing sunlight in the UVA range and thus generating ROS and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Fernblock^® (FB) is an aqueous extract from the leaves of <i>Polypodium leucotomos</i> that has been proven to exert photoprotective and antioxidant effects on skin cells. In this study, we evaluate the potential Antioxidants (Basel, Switzerland)Protective Effect of the Hydrophilic Extract of <i>Polypodium leucotomos</i>, Fernblock^®, against the Synergistic Action of UVA Radiation and Benzo[a]pyrene Pollutant.PMC9686834PI18/00708 and PI21PI18/00708PI21Nicolas-Morala JAlonso-Juarranz MPortillo-Esnaola MGallego-Rentero MRodriguez-Luna AGonzalez SCarrasco EfalseProtective Effect of the Hydrophilic Extract of <i>Polypodium leucotomos</i>, Fernblock^®, against the Synergistic Action of UVA Radiation and Benzo[a]pyrene Pollutant.Oxidative stress is a harmful effect induced on the skin by polycyclic aromatic hydrocarbons (PAH), including benzo[a]pyrene (BaP) air pollutants. This effect is amplified by the additive damaging effect of the sun, especially through the UVA light component. Besides being one of the main compounds that make up air pollution, BaP can also be found in tar, tobacco smoke, and various foods. In addition to its direct carcinogenic potential, BaP can act as a photosensitizer absorbing sunlight in the UVA range and thus generating ROS and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Fernblock^® (FB) is an aqueous extract from the leaves of <i>Polypodium leucotomos</i> that has been proven to exert photoprotective and antioxidant effects on skin cells. In this study, we evaluate the potential 2022-01-01T00:00:00Z2022 Nov2025-04-18T14:59:28.755Z2025-04-07T01:25:22.426ZS-EPMC96868343635855610.3390/antiox11112185