{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Machado MC"],"funding":["Coordenação de Aperfeicoamento de Pessoal de Nível Superior","SMBM","Foundation for Research Support of the State of Bahia","Fundação de Amparo à Pesquisa do Estado da Bahia","AEL","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil","National Council for Scientific and Technological Development","RDP"],"pagination":["3109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(22)"],"pubmed_abstract":["This prospective study aimed to evaluate the effect of metronomic cyclophosphamide on carboplatin’s tolerability, efficacy, and pharmacokinetics in dogs with mammary carcinoma. Sixteen female dogs with mammary carcinoma were divided into groups: 300 mg/m2 intravenous (i.v.) carboplatin therapy (G1 = 8) or 300 mg/m2 i.v. carboplatin which was associated with 12.5 mg/m2 oral cyclophosphamide in a metronomic regimen (G2 = 8). The investigated animals underwent a clinical evaluation, a mastectomy, a carboplatin chemotherapy, and serial blood sampling for the pharmacokinetic analysis. The adverse events and survival rates were monitored. A non-compartmental analysis was applied to calculate the pharmacokinetic parameters of carboplatin in the 2nd and 4th chemotherapy cycles. Carboplatin PK showed high interindividual variability with a 10-fold variation in the area under the plasma concentration−time curve (AUC) in G1. The systemic plasma exposure to carboplatin was equivalent in both of the treatments considering the AUC and maximum plasma concentration (Cmax) values. Although the red blood cells (p < 0.0001), platelets (p = 0.0005), total leukocytes (p = 0.0002), and segmented neutrophils (p = 0.0007) were reduced in G2, the survival rate increased (p = 0.0044) when it was compared to G1. In conclusion, adding low daily doses of cyclophosphamide to a carboplatin therapy showed promising outcomes in female dogs with mammary tumors."],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Pharmacokinetics of Carboplatin in Combination with Low-Dose Cyclophosphamide in Female Dogs with Mammary Carcinoma."],"pmcid":["PMC9686876"],"funding_grant_id":["001","310248/2021-3","313350/2019-1","312022/2021-2","023/2014"],"pubmed_authors":["Neves FMF","Pippa LF","Hielm-Bjorkman A","Estrela-Lima A","Godoy ALPC","Machado MC","Portela RD","Yamamoto PA","Barrouin-Melo SM","de Moraes NV"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacokinetics of Carboplatin in Combination with Low-Dose Cyclophosphamide in Female Dogs with Mammary Carcinoma.","description":"This prospective study aimed to evaluate the effect of metronomic cyclophosphamide on carboplatin’s tolerability, efficacy, and pharmacokinetics in dogs with mammary carcinoma. Sixteen female dogs with mammary carcinoma were divided into groups: 300 mg/m2 intravenous (i.v.) carboplatin therapy (G1 = 8) or 300 mg/m2 i.v. carboplatin which was associated with 12.5 mg/m2 oral cyclophosphamide in a metronomic regimen (G2 = 8). The investigated animals underwent a clinical evaluation, a mastectomy, a carboplatin chemotherapy, and serial blood sampling for the pharmacokinetic analysis. The adverse events and survival rates were monitored. A non-compartmental analysis was applied to calculate the pharmacokinetic parameters of carboplatin in the 2nd and 4th chemotherapy cycles. Carboplatin PK showed high interindividual variability with a 10-fold variation in the area under the plasma concentration−time curve (AUC) in G1. The systemic plasma exposure to carboplatin was equivalent in both of the treatments considering the AUC and maximum plasma concentration (Cmax) values. Although the red blood cells (p < 0.0001), platelets (p = 0.0005), total leukocytes (p = 0.0002), and segmented neutrophils (p = 0.0007) were reduced in G2, the survival rate increased (p = 0.0044) when it was compared to G1. In conclusion, adding low daily doses of cyclophosphamide to a carboplatin therapy showed promising outcomes in female dogs with mammary tumors.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T16:56:01.726Z","creation":"2025-04-07T04:25:17.851Z"},"accession":"S-EPMC9686876","cross_references":{"pubmed":["36428336"],"doi":["10.3390/ani12223109"]}}