{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang C"],"funding":["National Research Foundation of Korea"],"pagination":["2158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9686910"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["Some colorectal cancer (CRC) patients are resistant to 5-fluorouracil (5-FU), and high expression levels of thymidylate synthase (TS) contribute to this resistance. This study investigated whether quercetin, a representative polyphenol compound, could enhance the effect of 5-FU in CRC cells. Quercetin suppressed TS levels that were increased by 5-FU in CRC cells and promoted the expression of p53. Quercetin also induced intracellular and mitochondrial reactive oxygen species (ROS) production and Ca<sup>2+</sup> dysregulation in a 5-FU-independent pathway in CRC cells. Furthermore, quercetin decreased mitochondrial membrane potential in CRC cells and inhibited mitochondrial respiration. Moreover, quercetin regulated the expression of specific tiRNAs, including tiRNA<sup>HisGTG</sup>, and tr"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer."],"pmcid":["PMC9686910"],"funding_grant_id":["2021R1C1C1009807","2021R1A2C2005841"],"pubmed_authors":["Park W","Park H","Lim W","Hong T","Kim HS","Ham J","An G","Yang C","Park S","Song G","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer.","description":"Some colorectal cancer (CRC) patients are resistant to 5-fluorouracil (5-FU), and high expression levels of thymidylate synthase (TS) contribute to this resistance. This study investigated whether quercetin, a representative polyphenol compound, could enhance the effect of 5-FU in CRC cells. Quercetin suppressed TS levels that were increased by 5-FU in CRC cells and promoted the expression of p53. Quercetin also induced intracellular and mitochondrial reactive oxygen species (ROS) production and Ca<sup>2+</sup> dysregulation in a 5-FU-independent pathway in CRC cells. Furthermore, quercetin decreased mitochondrial membrane potential in CRC cells and inhibited mitochondrial respiration. Moreover, quercetin regulated the expression of specific tiRNAs, including tiRNA<sup>HisGTG</sup>, and tr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-05T10:57:42.075Z","creation":"2025-04-05T10:57:42.075Z"},"accession":"S-EPMC9686910","cross_references":{"pubmed":["36358529"],"doi":["10.3390/antiox11112158"]}}