{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(11)"],"submitter":["Merino D"],"pubmed_abstract":["Antipsychotic drugs (APs) aim to treat schizophrenia, bipolar mania, and behavioral symptoms. In child psychiatry, despite limited evidence regarding their efficacy and safety, APs are increasingly subject to off-label use. Studies investigating addictology-related symptoms in young people being scarce, we aimed to characterize the different patterns of AP misuse and withdrawal in children and adolescents relying on the WHO pharmacovigilance database (VigiBase<sup>®</sup>, Uppsala Monitoring Centre, Sweden). Using the standardized MedDRA Query 'drug abuse, dependence and withdrawal', disproportionality for each AP was assessed with the reporting odds ratio and the information component. A signal was detected when the lower end of the 95% confidence interval of the information component was"],"journal":["Biomedicines"],"pagination":["2972"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9687123"],"repository":["biostudies-literature"],"pubmed_title":["Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis."],"pmcid":["PMC9687123"],"pubmed_authors":["Destere A","Drici MD","Thummler S","Merino D","Gerard AO","Askenazy F"],"additional_accession":[]},"is_claimable":false,"name":"Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis.","description":"Antipsychotic drugs (APs) aim to treat schizophrenia, bipolar mania, and behavioral symptoms. In child psychiatry, despite limited evidence regarding their efficacy and safety, APs are increasingly subject to off-label use. Studies investigating addictology-related symptoms in young people being scarce, we aimed to characterize the different patterns of AP misuse and withdrawal in children and adolescents relying on the WHO pharmacovigilance database (VigiBase<sup>®</sup>, Uppsala Monitoring Centre, Sweden). Using the standardized MedDRA Query 'drug abuse, dependence and withdrawal', disproportionality for each AP was assessed with the reporting odds ratio and the information component. A signal was detected when the lower end of the 95% confidence interval of the information component was","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-05-18T12:01:46.021Z","creation":"2025-05-18T12:01:46.021Z"},"accession":"S-EPMC9687123","cross_references":{"pubmed":["36428541"],"doi":["10.3390/biomedicines10112972"]}}