{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(11)"],"submitter":["Cortez-Trejo MC"],"pubmed_abstract":["Pomegranate (PMG; <i>Punica granatum</i> L.) fruits possess a well-balanced nutrient/phytochemical composition, with proven adjuvant benefits in experimental cancer chemotherapy; however, such bioactivity could be affected by PMG's phenogenotype (varietal). Here, the chemical and phytochemical (UPLC-DAD-MS<sup>2</sup>) composition, antioxidant capacity and anticancer potential [in vitro (MTT assay) and in silico (foodinformatics)] of three PMG fruits of different aryl color [red (cv. Wonderful), pink (cv. Molar de Elche), and white (cv. Indian)] were evaluated. The macro/micronutrient (ascorbic acid, tocols, carotenoids), organic acid (citric/malic), and polyphenol content were changed by PMG's varietal and total antioxidant activity (ABTS, alcoholic &gt; hexane extract) in the order of red &gt; pink &gt; white. However, their in vitro cytotoxicity was the same (IC<sub>50</sub> &gt; 200 μg.mL<sup>-1</sup>) against normal (retinal) and cancer (breast, lung, colorectal) cell lines. Sixteen major phytochemicals were tentatively identified, four of them with a high GI absorption/bioavailability score [Ellagic (pink), vanillic (red), gallic (white) acids, D-(+)-catechin (white)] and three of them with multiple molecular targets [Ellagic (52) &gt; vanillic (32) &gt; gallic (23)] associated with anticancer (at initiation and promotion stages) activity. The anticancer potential of the PMG fruit is phenogenotype-specific, although it could be more effective in nutraceutical formulations (concentrates)."],"journal":["Biomolecules"],"pagination":["1649"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9687934"],"repository":["biostudies-literature"],"pubmed_title":["Potential Anticancer Activity of Pomegranate (<i>Punica granatum</i> L.) Fruits of Different Color: In Vitro and In Silico Evidence."],"pmcid":["PMC9687934"],"pubmed_authors":["Dufoo-Hurtado E","Olivas-Aguirre FJ","Wall-Medrano A","Cortez-Trejo MC","Mendoza S","Villegas-Quintero H","Castaneda-Moreno R","Medina-Franco JL"],"additional_accession":[]},"is_claimable":false,"name":"Potential Anticancer Activity of Pomegranate (<i>Punica granatum</i> L.) Fruits of Different Color: In Vitro and In Silico Evidence.","description":"Pomegranate (PMG; <i>Punica granatum</i> L.) fruits possess a well-balanced nutrient/phytochemical composition, with proven adjuvant benefits in experimental cancer chemotherapy; however, such bioactivity could be affected by PMG's phenogenotype (varietal). Here, the chemical and phytochemical (UPLC-DAD-MS<sup>2</sup>) composition, antioxidant capacity and anticancer potential [in vitro (MTT assay) and in silico (foodinformatics)] of three PMG fruits of different aryl color [red (cv. Wonderful), pink (cv. Molar de Elche), and white (cv. Indian)] were evaluated. The macro/micronutrient (ascorbic acid, tocols, carotenoids), organic acid (citric/malic), and polyphenol content were changed by PMG's varietal and total antioxidant activity (ABTS, alcoholic &gt; hexane extract) in the order of red &gt; pink &gt; white. However, their in vitro cytotoxicity was the same (IC<sub>50</sub> &gt; 200 μg.mL<sup>-1</sup>) against normal (retinal) and cancer (breast, lung, colorectal) cell lines. Sixteen major phytochemicals were tentatively identified, four of them with a high GI absorption/bioavailability score [Ellagic (pink), vanillic (red), gallic (white) acids, D-(+)-catechin (white)] and three of them with multiple molecular targets [Ellagic (52) &gt; vanillic (32) &gt; gallic (23)] associated with anticancer (at initiation and promotion stages) activity. The anticancer potential of the PMG fruit is phenogenotype-specific, although it could be more effective in nutraceutical formulations (concentrates).","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-05T15:21:37.228Z","creation":"2025-04-05T15:21:37.228Z"},"accession":"S-EPMC9687934","cross_references":{"pubmed":["36358999"],"doi":["10.3390/biom12111649"]}}