biostudies-literatureLiehr TState Committee of the Republic of Armenia2816https://www.ebi.ac.uk/biostudies/studies/S-EPMC9689121biostudies-literatureUnknown12(11)In the short 10 years following the introduction of non-invasive prenatal testing (NIPT), it has been adapted in many countries around the world as a standard screening test. In this review, this development was analyzed with a special focus on Germany. As a result, it can be stated that all known advantages of NIPT apart from "compensating for having no access to centers offering invasive diagnostics" are valid for Germany. In addition, following a review of the international literature, all documented issues with NIPT are also observed in Germany. However, the German Gene Diagnostics Act (GenDG) addresses a number of these issues, for example, the regulations by GenDG hamper induced abortions, based exclusively on an abnormal NIPT result. At the same time, GenDG has created new problems,Diagnostics (Basel, Switzerland)Non-Invasive Prenatal Testing in Germany.PMC9689121SC RA #21AG-1F068Liehr TWilliams HHarutyunyan TWeise AfalseNon-Invasive Prenatal Testing in Germany.In the short 10 years following the introduction of non-invasive prenatal testing (NIPT), it has been adapted in many countries around the world as a standard screening test. In this review, this development was analyzed with a special focus on Germany. As a result, it can be stated that all known advantages of NIPT apart from "compensating for having no access to centers offering invasive diagnostics" are valid for Germany. In addition, following a review of the international literature, all documented issues with NIPT are also observed in Germany. However, the German Gene Diagnostics Act (GenDG) addresses a number of these issues, for example, the regulations by GenDG hamper induced abortions, based exclusively on an abnormal NIPT result. At the same time, GenDG has created new problems,2022-01-01T00:00:00Z2022 Nov2025-04-19T00:35:39.122Z2025-04-07T11:40:17.869ZS-EPMC96891213642887610.3390/diagnostics12112816