biostudies-literatureCheng VCIHR8751-8766https://www.ebi.ac.uk/biostudies/studies/S-EPMC9689519biostudies-literatureUnknown29(11)Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched EMBASE and Medline from inception to June 2022. We included original, peer-reviewed studies that: used an epidemiologic design; included patients with CRC and a comparator group of individuals without cancer; and evaluated anxiety and depression as outcomes. We used random effects models to obtain pooled measures of associations. Quality assessment was completed using the Newcastle-Ottawa scale. Of 7326 articles identified, 8 were eligible; of which 6 assessed anxiety and depression and 2 assessCurrent oncology (Toronto, Ont.)Colorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis.PMC9689519PJT-159467McTaggart-Cowan HCheng VLoree JMOveisi NDe Vera MAMurphy RAfalseColorectal Cancer and Onset of Anxiety and Depression: A Systematic Review and Meta-Analysis.Research suggests that colorectal cancer (CRC) is associated with mental health disorders, primarily anxiety and depression. To synthesize this evidence, we conducted a systematic review and meta-analysis of studies evaluating the onset of anxiety and depression among patients with CRC. We searched EMBASE and Medline from inception to June 2022. We included original, peer-reviewed studies that: used an epidemiologic design; included patients with CRC and a comparator group of individuals without cancer; and evaluated anxiety and depression as outcomes. We used random effects models to obtain pooled measures of associations. Quality assessment was completed using the Newcastle-Ottawa scale. Of 7326 articles identified, 8 were eligible; of which 6 assessed anxiety and depression and 2 assess2022-01-01T00:00:00Z2022 Nov2025-04-05T15:21:55.871Z2025-04-05T15:21:55.871ZS-EPMC96895193642134210.3390/curroncol29110689