biostudies-literatureUnknown13(11)Golabek KOral squamous cell carcinoma (OSCC) is one of the most prevalent types of cancers worldwide. LTF arrests the G1 to S phase transition of the cell cycle. This study is the first that has aimed to determine the possible association between the <i>LTF</i> polymorphisms (rs2073495, rs1126478, rs34827868, rs1042073, rs4637321, rs2239692 and rs10865941), the mRNA <i>LTF</i> expression, the risk of OSCC and the influence on the TNM staging and histological grading. This study was composed of 176 Polish patients, including 88 subjects diagnosed with OSCC and 88 healthy individuals. QuantStudio Design and Analysis Software v1.5.1 was used for the single nucleotide polymorphism (SNP) analysis and mRNA <i>LTF</i> expression. The G/G genotype of rs2073495 and the G/G genotype of rs4637321 were linked,Genes2085https://www.ebi.ac.uk/biostudies/studies/S-EPMC9690716biostudies-literatureSingle Nucleotide Polymorphism and mRNA Expression of <i>LTF</i> in Oral Squamous Cell Carcinoma.PMC9690716Miskiewicz-Orczyk KAsman MRaczka GKrakowczyk LZieba NHudy DStrzelczyk JKMisiolek MGolabek KGazdzicka JfalseSingle Nucleotide Polymorphism and mRNA Expression of <i>LTF</i> in Oral Squamous Cell Carcinoma.Oral squamous cell carcinoma (OSCC) is one of the most prevalent types of cancers worldwide. LTF arrests the G1 to S phase transition of the cell cycle. This study is the first that has aimed to determine the possible association between the <i>LTF</i> polymorphisms (rs2073495, rs1126478, rs34827868, rs1042073, rs4637321, rs2239692 and rs10865941), the mRNA <i>LTF</i> expression, the risk of OSCC and the influence on the TNM staging and histological grading. This study was composed of 176 Polish patients, including 88 subjects diagnosed with OSCC and 88 healthy individuals. QuantStudio Design and Analysis Software v1.5.1 was used for the single nucleotide polymorphism (SNP) analysis and mRNA <i>LTF</i> expression. The G/G genotype of rs2073495 and the G/G genotype of rs4637321 were linked,2022-01-01T00:00:00Z2022 Nov2025-06-01T12:01:33.267Z2024-12-04T01:41:03.236ZS-EPMC96907163636032210.3390/genes13112085