{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(22)"],"submitter":["Merulla AE"],"pubmed_abstract":["The involvement of non-coding RNAs (ncRNAs) in glioblastoma multiforme (GBM) pathogenesis and progression has been ascertained but their cross-talk within GBM cells remains elusive. We previously demonstrated the role of circSMARCA5 as a tumor suppressor (TS) in GBM. In this paper, we explore the involvement of circSMARCA5 in the control of microRNA (miRNA) expression in GBM. By using TaqMan<sup>®</sup> low-density arrays, the expression of 748 miRNAs was assayed in U87MG overexpressing circSMARCA5. Differentially expressed (DE) miRNAs were validated through single TaqMan<sup>®</sup> assays in: (i) U87MG overexpressing circSMARCA5; (ii) four additional GBM cell lines (A172; CAS-1; SNB-19; U251MG); (iii) thirty-eight GBM biopsies; (iv) twenty biopsies of unaffected brain parenchyma (UC). Va"],"journal":["International journal of molecular sciences"],"pagination":["13676"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9690846"],"repository":["biostudies-literature"],"pubmed_title":["circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, <i>Insulin-like Growth Factor Binding Protein 2</i> (<i>IGFBP2</i>) and <i>NRAS Proto-Oncogene, GTPase</i> (<i>NRAS</i>) in Glioblastoma."],"pmcid":["PMC9690846"],"pubmed_authors":["Merulla AE","Caltabiano R","Battaglia R","Certo F","Broggi G","Di Pietro C","Altieri R","Barbagallo GMV","Stella M","Purrello M","Caponnetto A","Ragusa M","Barbagallo D","Barbagallo C"],"additional_accession":[]},"is_claimable":false,"name":"circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, <i>Insulin-like Growth Factor Binding Protein 2</i> (<i>IGFBP2</i>) and <i>NRAS Proto-Oncogene, GTPase</i> (<i>NRAS</i>) in Glioblastoma.","description":"The involvement of non-coding RNAs (ncRNAs) in glioblastoma multiforme (GBM) pathogenesis and progression has been ascertained but their cross-talk within GBM cells remains elusive. We previously demonstrated the role of circSMARCA5 as a tumor suppressor (TS) in GBM. In this paper, we explore the involvement of circSMARCA5 in the control of microRNA (miRNA) expression in GBM. By using TaqMan<sup>®</sup> low-density arrays, the expression of 748 miRNAs was assayed in U87MG overexpressing circSMARCA5. Differentially expressed (DE) miRNAs were validated through single TaqMan<sup>®</sup> assays in: (i) U87MG overexpressing circSMARCA5; (ii) four additional GBM cell lines (A172; CAS-1; SNB-19; U251MG); (iii) thirty-eight GBM biopsies; (iv) twenty biopsies of unaffected brain parenchyma (UC). Va","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T13:28:01.983Z","creation":"2025-02-19T04:37:21.076Z"},"accession":"S-EPMC9690846","cross_references":{"pubmed":["36430152"],"doi":["10.3390/ijms232213676"]}}