biostudies-literatureUnknown38(6)Lee WL<h4>Background</h4>A significant proportion of acute coronary syndrome (ACS) patients experience high on-treatment platelet reactivity (HPR) on clopidogrel-based dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).<h4>Objectives</h4>This study assessed key independent risk factors associated with significant HPR risk on clopidogrel, but not prasugrel, in the Switch Study cohort of 200 Taiwanese ACS patients who switched from clopidogrel to low-dose prasugrel for maintenance DAPT after PCI.<h4>Methods</h4>Univariate analysis and stepwise multivariate logistic regression analysis were conducted to identify key independent risk factors for HPR on clopidogrel, but not prasugrel.<h4>Results</h4>A HANC [H: low hemoglobin (< 13 g/dL for men and < 12 g/dL for women); A:Acta Cardiologica Sinica751-764https://www.ebi.ac.uk/biostudies/studies/S-EPMC9692225biostudies-literatureA HANC Risk Stratification Score for Antiplatelet Therapy Optimization with Low-Dose Prasugrel in Taiwanese Acute Coronary Syndrome Patients from the Switch Study.PMC9692225Lin WSSu CHYang WCWang YCLee WLSu CSYin WHChu PHKuo FYCheng LCLu TMLo PHLin YHLiu PYTsukiyama SLee HFTung YCfalseA HANC Risk Stratification Score for Antiplatelet Therapy Optimization with Low-Dose Prasugrel in Taiwanese Acute Coronary Syndrome Patients from the Switch Study.<h4>Background</h4>A significant proportion of acute coronary syndrome (ACS) patients experience high on-treatment platelet reactivity (HPR) on clopidogrel-based dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).<h4>Objectives</h4>This study assessed key independent risk factors associated with significant HPR risk on clopidogrel, but not prasugrel, in the Switch Study cohort of 200 Taiwanese ACS patients who switched from clopidogrel to low-dose prasugrel for maintenance DAPT after PCI.<h4>Methods</h4>Univariate analysis and stepwise multivariate logistic regression analysis were conducted to identify key independent risk factors for HPR on clopidogrel, but not prasugrel.<h4>Results</h4>A HANC [H: low hemoglobin (< 13 g/dL for men and < 12 g/dL for women); A:2022-01-01T00:00:00Z2022 Nov2025-06-01T03:54:59.913Z2024-12-04T12:35:02.133ZS-EPMC96922253644025010.6515/ACS.202211_38(6).20220702A10.6515/acs.202211_38(6).20220702a