biostudies-literatureKuo SCNational Health Research Institutes, Zhunan, Miaoli County, Taiwan376https://www.ebi.ac.uk/biostudies/studies/S-EPMC9693367biostudies-literatureUnknown7(11)This modeling study considers different screening strategies, contact tracing, and the severity of novel epidemic outbreaks for various population sizes, providing insight into multinational containment effectiveness of emerging infectious diseases, prior to vaccines development. During the period of the ancestral SARS-Cov-2 virus, contact tracing alone is insufficient to achieve outbreak control. Although universal testing is proposed in multiple nations, its effectiveness accompanied by other measures is rarely examined. Our research investigates the necessity of universal testing when contact tracing and symptomatic screening measures are implemented. We used a stochastic transmission model to simulate COVID-19 transmission, evaluating containment strategies via contact tracing, one-timTropical medicine and infectious diseaseContribution of Testing Strategies and Contact Tracing towards COVID-19 Outbreaks Control: A Mathematical Modeling Study.PMC9693367PH-110-GP-02PH-111-PP-02PH-109-PP-02PH-110-PP-02PH-111-GP-02Tsou HHWu MHWu SIZhu HWu HYChiou HYKuo SCLee FJHsu YTHsiung CACheng YCFan BChen WJSytwu HKfalseContribution of Testing Strategies and Contact Tracing towards COVID-19 Outbreaks Control: A Mathematical Modeling Study.This modeling study considers different screening strategies, contact tracing, and the severity of novel epidemic outbreaks for various population sizes, providing insight into multinational containment effectiveness of emerging infectious diseases, prior to vaccines development. During the period of the ancestral SARS-Cov-2 virus, contact tracing alone is insufficient to achieve outbreak control. Although universal testing is proposed in multiple nations, its effectiveness accompanied by other measures is rarely examined. Our research investigates the necessity of universal testing when contact tracing and symptomatic screening measures are implemented. We used a stochastic transmission model to simulate COVID-19 transmission, evaluating containment strategies via contact tracing, one-tim2022-01-01T00:00:00Z2022 Nov2025-04-05T10:57:16.047Z2025-04-05T10:57:16.047ZS-EPMC96933673642292610.3390/tropicalmed7110376