{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["China Agriculture Research System of MOF and MARA","National Key R&amp;amp;D Program of China","State Key Laboratory of Animal Nutrition Project","National Natural Science Foundation of China"],"pagination":["801"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9693499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["Citrinin (CIT) is a mycotoxin found in foods and feeds and most commonly discovered in red yeast rice, a food additive made from ordinary rice by fermentation with <i>Monascus</i>. Currently, no enzyme is known to be able to degrade CIT effectively. In this study, it was discovered that manganese peroxidase (<i>Mr</i>MnP) from <i>Moniliophthora roreri</i> could degrade CIT. The degradation appeared to be fulfilled by a combination of direct and indirect actions of the <i>Mr</i>MnP with the CIT. Pure CIT, at a final concentration of 10 mg/L, was completely degraded by <i>Mr</i>MnP within 72 h. One degradation product was identified to be dihydrocitrinone. The toxicity of the CIT-degradation product decreased, as monitored by the increased survival rate of the Caco-2 cells incubated with <i>"],"journal":["Toxins"],"pubmed_title":["Detoxification of the Mycotoxin Citrinin by a Manganese Peroxidase from <i>Moniliophthora&nbsp;roreri</i>."],"pmcid":["PMC9693499"],"funding_grant_id":["2021YFC2102400","2004DA125184G2101","32220103011","CARS-41","2021YFC2103002"],"pubmed_authors":["Zhang W","Tu T","Wang S","Zhang Y","Huang H","Liu B","Yao B","Wang X","Luo H","Su X"],"additional_accession":[]},"is_claimable":false,"name":"Detoxification of the Mycotoxin Citrinin by a Manganese Peroxidase from <i>Moniliophthora&nbsp;roreri</i>.","description":"Citrinin (CIT) is a mycotoxin found in foods and feeds and most commonly discovered in red yeast rice, a food additive made from ordinary rice by fermentation with <i>Monascus</i>. Currently, no enzyme is known to be able to degrade CIT effectively. In this study, it was discovered that manganese peroxidase (<i>Mr</i>MnP) from <i>Moniliophthora roreri</i> could degrade CIT. The degradation appeared to be fulfilled by a combination of direct and indirect actions of the <i>Mr</i>MnP with the CIT. Pure CIT, at a final concentration of 10 mg/L, was completely degraded by <i>Mr</i>MnP within 72 h. One degradation product was identified to be dihydrocitrinone. The toxicity of the CIT-degradation product decreased, as monitored by the increased survival rate of the Caco-2 cells incubated with <i>","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-08T03:12:21.959Z","creation":"2025-02-19T03:23:32.398Z"},"accession":"S-EPMC9693499","cross_references":{"pubmed":["36422974"],"doi":["10.3390/toxins14110801"]}}