{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Chen KC"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pubmed_abstract":["<h4>Background</h4>The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels.<h4>Methods</h4>We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia.<"],"journal":["Psychological medicine"],"pagination":["1-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9693693"],"repository":["biostudies-literature"],"pubmed_title":["Striatal dopamine D<sub>2/3</sub> receptors in medication-naive schizophrenia: an [<sup>123</sup>I] IBZM SPECT study."],"pmcid":["PMC9693693"],"funding_grant_id":["PDA/02/06/016","NIHR200756","G0901310"],"pubmed_authors":["Chen KC","Yeh TL","Chiu NT","David AS","Howes OD","Lee IH","Chen PS","Bramon E","Yang YK"],"additional_accession":[]},"is_claimable":false,"name":"Striatal dopamine D<sub>2/3</sub> receptors in medication-naive schizophrenia: an [<sup>123</sup>I] IBZM SPECT study.","description":"<h4>Background</h4>The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels.<h4>Methods</h4>We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia.<","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-19T23:05:20.722Z","creation":"2025-04-19T23:05:20.722Z"},"accession":"S-EPMC9693693","cross_references":{"pubmed":["33682657"],"doi":["10.1017/S0033291720005413"]}}