biostudies-literatureUnknownChen KCMedical Research CouncilNational Institute for Health Research (NIHR)<h4>Background</h4>The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels.<h4>Methods</h4>We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia.<Psychological medicine1-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC9693693biostudies-literatureStriatal dopamine D_2/3 receptors in medication-naive schizophrenia: an [¹²³I] IBZM SPECT study.PMC9693693PDA/02/06/016NIHR200756G0901310Chen KCYeh TLChiu NTDavid ASHowes ODLee IHChen PSBramon EYang YKfalseStriatal dopamine D_2/3 receptors in medication-naive schizophrenia: an [¹²³I] IBZM SPECT study.<h4>Background</h4>The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels.<h4>Methods</h4>We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia.<2021-01-01T00:00:00Z2021 Mar2025-04-19T23:05:20.722Z2025-04-19T23:05:20.722ZS-EPMC96936933368265710.1017/S0033291720005413