{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Herzog P"],"pubmed_abstract":["Borderline personality disorder (BPD) is a severe mental disorder, comprised of heterogeneous psychological and neurobiological pathologies. Here, we propose a predictive processing (PP) account of BPD to integrate these seemingly unrelated pathologies. In particular, we argue that the experience of childhood maltreatment, which is highly prevalent in BPD, leaves a developmental legacy with two facets: first, a coarse-grained, alexithymic model of self and others - leading to a rigidity and inflexibility concerning beliefs about self and others. Second, this developmental legacy leads to a loss of confidence or precision afforded beliefs about the consequences of social behavior. This results in an over reliance on sensory evidence and social feedback, with concomitant lability, impulsivit"],"journal":["Psychological medicine"],"pagination":["1-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9693729"],"repository":["biostudies-literature"],"pubmed_title":["How childhood maltreatment alters perception and cognition - the predictive processing account of borderline personality disorder."],"pmcid":["PMC9693729"],"pubmed_authors":["Herzog P","Fassbinder E","Kube T"],"additional_accession":[]},"is_claimable":false,"name":"How childhood maltreatment alters perception and cognition - the predictive processing account of borderline personality disorder.","description":"Borderline personality disorder (BPD) is a severe mental disorder, comprised of heterogeneous psychological and neurobiological pathologies. Here, we propose a predictive processing (PP) account of BPD to integrate these seemingly unrelated pathologies. In particular, we argue that the experience of childhood maltreatment, which is highly prevalent in BPD, leaves a developmental legacy with two facets: first, a coarse-grained, alexithymic model of self and others - leading to a rigidity and inflexibility concerning beliefs about self and others. Second, this developmental legacy leads to a loss of confidence or precision afforded beliefs about the consequences of social behavior. This results in an over reliance on sensory evidence and social feedback, with concomitant lability, impulsivit","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T23:07:32.284Z","creation":"2025-04-19T23:07:32.284Z"},"accession":"S-EPMC9693729","cross_references":{"pubmed":["35979924"],"doi":["10.1017/S0033291722002458"]}}