{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Lin WY"],"pubmed_abstract":["The <i>found in neurons</i> (<i>fne</i>), a paralog of the RNA-binding protein <i>ELAV</i> gene family in <i>Drosophila</i>, is required for post-transcriptional regulation of neuronal development and differentiation. Previous explorations into the functions of the FNE protein have been limited to neurons. The function of <i>fne</i> in <i>Drosophila</i> glia remains unclear. We induced the knockdown or overexpression of <i>fne</i> in <i>Drosophila</i> neurons and glia to determine how <i>fne</i> affects different types of behaviors, neuronal transmission and the lifespan. Our data indicate that changes in <i>fne</i> expression impair associative learning, thermal nociception, and phototransduction. Examination of synaptic transmission at presynaptic and postsynaptic terminals of the larval"],"journal":["Frontiers in molecular neuroscience"],"pagination":["1006455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9693765"],"repository":["biostudies-literature"],"pubmed_title":["Alterations of RNA-binding protein <i>found in neurons</i> in <i>Drosophila</i> neurons and glia influence synaptic transmission and lifespan."],"pmcid":["PMC9693765"],"pubmed_authors":["Liu CH","Lin WY","Liu HP","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"Alterations of RNA-binding protein <i>found in neurons</i> in <i>Drosophila</i> neurons and glia influence synaptic transmission and lifespan.","description":"The <i>found in neurons</i> (<i>fne</i>), a paralog of the RNA-binding protein <i>ELAV</i> gene family in <i>Drosophila</i>, is required for post-transcriptional regulation of neuronal development and differentiation. Previous explorations into the functions of the FNE protein have been limited to neurons. The function of <i>fne</i> in <i>Drosophila</i> glia remains unclear. We induced the knockdown or overexpression of <i>fne</i> in <i>Drosophila</i> neurons and glia to determine how <i>fne</i> affects different types of behaviors, neuronal transmission and the lifespan. Our data indicate that changes in <i>fne</i> expression impair associative learning, thermal nociception, and phototransduction. Examination of synaptic transmission at presynaptic and postsynaptic terminals of the larval","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T14:13:15.638Z","creation":"2024-12-04T01:22:39.672Z"},"accession":"S-EPMC9693765","cross_references":{"pubmed":["36438188"],"doi":["10.3389/fnmol.2022.1006455"]}}