{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26"],"submitter":["Aquino-Acevedo AN"],"pubmed_abstract":["Mounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in ovarian cancer cells, and induction of pro-tumoral signaling pathways. In addition, data suggest that chronic stress promotes an inflammatory landscape highlighted by increased infiltration of tumor-associated macrophages into the ovarian tumor microenvironment (TME). In ovarian cancer, ascites is a unique TME comprised of tumor, and immune cells, which secrete pro-tumoral cytokines and chemokines that modulate tumor-associated immunity. However, our knowledge about how stress hormones impact the ascites TME remains limited. We hypothesized that "],"journal":["Brain, behavior, & immunity - health"],"pagination":["100558"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9694096"],"repository":["biostudies-literature"],"pubmed_title":["Stress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer."],"pmcid":["PMC9694096"],"pubmed_authors":["Previs RA","Armaiz-Pena GN","Ortiz-Leon M","Whitaker R","Yi JS","Cruz-Robles ME","Aquino-Acevedo AN","Dutil J","Knochenhauer H","Castillo-Ocampo Y","Russell S","Morales-Lopez C","Bonilla-Claudio M","Gaillard SL","Hernandez-Cordero ER","Chen DT","Rivera-Lopez YA"],"additional_accession":[]},"is_claimable":false,"name":"Stress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer.","description":"Mounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in ovarian cancer cells, and induction of pro-tumoral signaling pathways. In addition, data suggest that chronic stress promotes an inflammatory landscape highlighted by increased infiltration of tumor-associated macrophages into the ovarian tumor microenvironment (TME). In ovarian cancer, ascites is a unique TME comprised of tumor, and immune cells, which secrete pro-tumoral cytokines and chemokines that modulate tumor-associated immunity. However, our knowledge about how stress hormones impact the ascites TME remains limited. We hypothesized that ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T19:51:14.348Z","creation":"2025-04-04T19:51:14.348Z"},"accession":"S-EPMC9694096","cross_references":{"pubmed":["36439058"],"doi":["10.1016/j.bbih.2022.100558"]}}