biostudies-literatureUnknown26Aquino-Acevedo ANMounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in ovarian cancer cells, and induction of pro-tumoral signaling pathways. In addition, data suggest that chronic stress promotes an inflammatory landscape highlighted by increased infiltration of tumor-associated macrophages into the ovarian tumor microenvironment (TME). In ovarian cancer, ascites is a unique TME comprised of tumor, and immune cells, which secrete pro-tumoral cytokines and chemokines that modulate tumor-associated immunity. However, our knowledge about how stress hormones impact the ascites TME remains limited. We hypothesized that Brain, behavior, & immunity - health100558https://www.ebi.ac.uk/biostudies/studies/S-EPMC9694096biostudies-literatureStress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer.PMC9694096Previs RAArmaiz-Pena GNOrtiz-Leon MWhitaker RYi JSCruz-Robles MEAquino-Acevedo ANDutil JKnochenhauer HCastillo-Ocampo YRussell SMorales-Lopez CBonilla-Claudio MGaillard SLHernandez-Cordero ERChen DTRivera-Lopez YAfalseStress hormones are associated with inflammatory cytokines and attenuation of T-cell function in the ascites from patients with high grade serous ovarian cancer.Mounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in ovarian cancer cells, and induction of pro-tumoral signaling pathways. In addition, data suggest that chronic stress promotes an inflammatory landscape highlighted by increased infiltration of tumor-associated macrophages into the ovarian tumor microenvironment (TME). In ovarian cancer, ascites is a unique TME comprised of tumor, and immune cells, which secrete pro-tumoral cytokines and chemokines that modulate tumor-associated immunity. However, our knowledge about how stress hormones impact the ascites TME remains limited. We hypothesized that 2022-01-01T00:00:00Z2022 Dec2025-04-04T19:51:14.348Z2025-04-04T19:51:14.348ZS-EPMC96940963643905810.1016/j.bbih.2022.100558