{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abrantes M"],"funding":["Fundação para a Ciência e a Tecnologia","\"la Caixa\" Foundation","Branco Weiss Fellowship – Society in Science","“la Caixa” Foundation"],"pagination":["495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9694542"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Detecting physiological levels of neurotransmitters in biological samples can advance our understanding of brain disorders and lead to improved diagnostics and therapeutics. However, neurotransmitter sensors for real-world applications must reliably detect low concentrations of target analytes from small volume working samples. Herein, a platform for robust and ultrasensitive detection of dopamine, an essential neurotransmitter that underlies several brain disorders, based on graphene multitransistor arrays (gMTAs) functionalized with a selective DNA aptamer is presented. High-yield scalable methodologies optimized at the wafer level were employed to integrate multiple graphene transistors on small-size chips (4.5 × 4.5 mm). The multiple sensor array configuration permits independent and s"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays."],"pmcid":["PMC9694542"],"funding_grant_id":["LCF/PR/HR21-00410","UIDB/50026/2020; UIDP/50026/2020; PTDC/MED-NEU/28073/2017 (POCI-01-307 0145-FEDER-028073)"],"pubmed_authors":["Abrantes M","Domingues T","Rodrigues D","Monteiro P","Borme J","Alpuim P","Nemala SS","Jacinto L"],"additional_accession":[]},"is_claimable":false,"name":"Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays.","description":"Detecting physiological levels of neurotransmitters in biological samples can advance our understanding of brain disorders and lead to improved diagnostics and therapeutics. However, neurotransmitter sensors for real-world applications must reliably detect low concentrations of target analytes from small volume working samples. Herein, a platform for robust and ultrasensitive detection of dopamine, an essential neurotransmitter that underlies several brain disorders, based on graphene multitransistor arrays (gMTAs) functionalized with a selective DNA aptamer is presented. High-yield scalable methodologies optimized at the wafer level were employed to integrate multiple graphene transistors on small-size chips (4.5 × 4.5 mm). The multiple sensor array configuration permits independent and s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-06-01T02:31:29.323Z","creation":"2024-11-15T06:58:39.591Z"},"accession":"S-EPMC9694542","cross_references":{"pubmed":["36424623"],"doi":["10.1186/s12951-022-01695-0"]}}