biostudies-literatureAbrantes MFundação para a Ciência e a Tecnologia"la Caixa" FoundationBranco Weiss Fellowship – Society in Science“la Caixa” Foundation495https://www.ebi.ac.uk/biostudies/studies/S-EPMC9694542biostudies-literatureUnknown20(1)Detecting physiological levels of neurotransmitters in biological samples can advance our understanding of brain disorders and lead to improved diagnostics and therapeutics. However, neurotransmitter sensors for real-world applications must reliably detect low concentrations of target analytes from small volume working samples. Herein, a platform for robust and ultrasensitive detection of dopamine, an essential neurotransmitter that underlies several brain disorders, based on graphene multitransistor arrays (gMTAs) functionalized with a selective DNA aptamer is presented. High-yield scalable methodologies optimized at the wafer level were employed to integrate multiple graphene transistors on small-size chips (4.5 × 4.5 mm). The multiple sensor array configuration permits independent and sJournal of nanobiotechnologyUltrasensitive dopamine detection with graphene aptasensor multitransistor arrays.PMC9694542LCF/PR/HR21-00410UIDB/50026/2020; UIDP/50026/2020; PTDC/MED-NEU/28073/2017 (POCI-01-307 0145-FEDER-028073)Abrantes MDomingues TRodrigues DMonteiro PBorme JAlpuim PNemala SSJacinto LfalseUltrasensitive dopamine detection with graphene aptasensor multitransistor arrays.Detecting physiological levels of neurotransmitters in biological samples can advance our understanding of brain disorders and lead to improved diagnostics and therapeutics. However, neurotransmitter sensors for real-world applications must reliably detect low concentrations of target analytes from small volume working samples. Herein, a platform for robust and ultrasensitive detection of dopamine, an essential neurotransmitter that underlies several brain disorders, based on graphene multitransistor arrays (gMTAs) functionalized with a selective DNA aptamer is presented. High-yield scalable methodologies optimized at the wafer level were employed to integrate multiple graphene transistors on small-size chips (4.5 × 4.5 mm). The multiple sensor array configuration permits independent and s2022-01-01T00:00:00Z2022 Nov2025-06-01T02:31:29.323Z2024-11-15T06:58:39.591ZS-EPMC96945423642462310.1186/s12951-022-01695-0