{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song Z"],"funding":["CAMS Innovation Fund for Medical Sciences"],"pagination":["2451"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9694983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["Small molecular nucleic acid drugs produce antiviral effects by activating pattern recognition receptors (PRRs). In this study, a small molecular nucleotide containing 5'triphosphoric acid (5'PPP) and possessing a double-stranded structure was designed and named nCoV-L. nCoV-L was found to specifically activate RIG-I, induce interferon responses, and inhibit duplication of four RNA viruses (Human enterovirus 71, Human poliovirus 1, Huma<i>n</i> coxsackievirus B5 and Influenza A virus) in cells. In vivo, nCoV-L quickly induced interferon responses and protected BALB/c suckling mice from a lethal dose of the enterovirus 71. Additionally, prophylactic administration of nCoV-L was found to reduce mouse death and relieve morbidity symptoms in a K18-hACE2 mouse lethal model of SARS-CoV-2. In sum"],"journal":["Viruses"],"pubmed_title":["A Short 5'triphosphate RNA nCoV-L Induces a Broad-Spectrum Antiviral Response by Activating RIG-I."],"pmcid":["PMC9694983"],"funding_grant_id":["2021-I2M-5-005"],"pubmed_authors":["Liu J","Zhang J","Mao Q","Liang Z","He Q","Bai Y","Gao F","An C","Song L","Li X","Wang Q","Bian L","Liu D","Song Z","Cui B","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"A Short 5'triphosphate RNA nCoV-L Induces a Broad-Spectrum Antiviral Response by Activating RIG-I.","description":"Small molecular nucleic acid drugs produce antiviral effects by activating pattern recognition receptors (PRRs). In this study, a small molecular nucleotide containing 5'triphosphoric acid (5'PPP) and possessing a double-stranded structure was designed and named nCoV-L. nCoV-L was found to specifically activate RIG-I, induce interferon responses, and inhibit duplication of four RNA viruses (Human enterovirus 71, Human poliovirus 1, Huma<i>n</i> coxsackievirus B5 and Influenza A virus) in cells. In vivo, nCoV-L quickly induced interferon responses and protected BALB/c suckling mice from a lethal dose of the enterovirus 71. Additionally, prophylactic administration of nCoV-L was found to reduce mouse death and relieve morbidity symptoms in a K18-hACE2 mouse lethal model of SARS-CoV-2. In sum","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T20:32:12.305Z","creation":"2025-04-07T08:25:02.479Z"},"accession":"S-EPMC9694983","cross_references":{"pubmed":["36366549"],"doi":["10.3390/v14112451"]}}