biostudies-literatureZhang HExcellent Young Scientist Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaResearch Units of Adaptive Evolution and Control of Emerging Viruses, Chinese Academy of Medical Sciences2332https://www.ebi.ac.uk/biostudies/studies/S-EPMC9696057biostudies-literatureUnknown14(11)Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity. Herein, we have depicted the profile of CD8+ and CD4+ T cell immunogenicity of ZIKV proteins in C57BL/6 (H-2^b) and BALB/c (H-2^d) mice, and found that featured cellular immunity antigens were variant among different murine alleles. In H-2^b mice, the proteins E, NS2, NS3 and NS5 are recognized as immunodominant antigens by CD8+ T cells, while NS4 is dominantly recognized by CD4+ T cells. In contrast, in H-2^d mice, NS1 and NS4 are the dominant CD8+ T cell antigen and NS4 as the dominant CD4+ T cell antigen, respectively. Among the synthesized 364 overlapping poVirusesThe CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets.PMC96960572018RU009818220408216114800881971501Zhang FPeng WZhang JLu XZhang HYe BLiu PXiao WLu DLiu SWu GZhao YZhang QShu LZhao MWang PLi SZhang YLiu WJLu STan SZong KGao GFZhou JfalseThe CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets.Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity. Herein, we have depicted the profile of CD8+ and CD4+ T cell immunogenicity of ZIKV proteins in C57BL/6 (H-2^b) and BALB/c (H-2^d) mice, and found that featured cellular immunity antigens were variant among different murine alleles. In H-2^b mice, the proteins E, NS2, NS3 and NS5 are recognized as immunodominant antigens by CD8+ T cells, while NS4 is dominantly recognized by CD4+ T cells. In contrast, in H-2^d mice, NS1 and NS4 are the dominant CD8+ T cell antigen and NS4 as the dominant CD4+ T cell antigen, respectively. Among the synthesized 364 overlapping po2022-01-01T00:00:00Z2022 Oct2026-05-10T03:13:23.05Z2024-11-07T00:33:44.193ZS-EPMC96960573636643010.3390/v14112332