biostudies-literatureGele TAgence Nationale de la RechercheAgence Nationale de Recherches sur le Sida et les Hépatites Virales2282https://www.ebi.ac.uk/biostudies/studies/S-EPMC9696548biostudies-literatureUnknown14(11)The development of animal models undergoing long-term antiretroviral treatment (ART) makes it possible to understand a number of immunological, virological, and pharmacological issues, key factors in the management of HIV infection. We aimed to pharmacologically validate a non-human primate (NHP) model treated in the long term with antiretroviral drugs after infection with the pathogenic SIVmac251 strain. A single-dose pharmacokinetic study of tenofovir disoproxil fumarate, emtricitabine, and dolutegravir was first conducted on 13 non-infected macaques to compare three different routes of administration. Then, 12 simian immunodeficiency virus (SIV)-infected (SIV⁺) macaques were treated with the same regimen for two years. Drug monitoring, virological efficacy, and safety were evPharmaceuticsPharmacological Validation of Long-Term Treatment with Antiretroviral Drugs in a Model of SIV-Infected Non-Human Primates.PMC9696548ANR-10-EQPX-02-01SIVART ANRS-IDMIT CO1ANR-11- INBS-0008Desjardins DGele TLe Grand RGouget HBarrail-Tran ALambotte ODereuddre-Bosquet NFurlan VfalsePharmacological Validation of Long-Term Treatment with Antiretroviral Drugs in a Model of SIV-Infected Non-Human Primates.The development of animal models undergoing long-term antiretroviral treatment (ART) makes it possible to understand a number of immunological, virological, and pharmacological issues, key factors in the management of HIV infection. We aimed to pharmacologically validate a non-human primate (NHP) model treated in the long term with antiretroviral drugs after infection with the pathogenic SIVmac251 strain. A single-dose pharmacokinetic study of tenofovir disoproxil fumarate, emtricitabine, and dolutegravir was first conducted on 13 non-infected macaques to compare three different routes of administration. Then, 12 simian immunodeficiency virus (SIV)-infected (SIV⁺) macaques were treated with the same regimen for two years. Drug monitoring, virological efficacy, and safety were ev2022-01-01T00:00:00Z2022 Oct2025-04-04T19:51:56.902Z2025-04-04T19:51:56.902ZS-EPMC96965483636510110.3390/pharmaceutics14112282