{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(11)"],"submitter":["Begum S"],"pubmed_abstract":["Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate. The aim of the current study was to implement immunoinformatics approaches to infer sequence- and structure-based molecular mimicry between viral and human proteomic datasets. The protein sequences of all the so far known human-infecting viruses were obtained from the VIPR database, and complete human proteome data were retrieved from the NCBI repository. Based on a predefined, stringent threshold of comparative sequence analyses, 24 viral proteins were identified with significant sequence similarity to human proteins. PathDIP identified the enrichment of these homologou"],"journal":["Pathogens (Basel, Switzerland)"],"pagination":["1362"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9696880"],"repository":["biostudies-literature"],"pubmed_title":["Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity."],"pmcid":["PMC9696880"],"pubmed_authors":["Allahyani M","Aljuaid A","Ahmad S","Begum S","Khan A","Aiman S","Samad A","Almehmadi M","Afridi SG"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity.","description":"Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate. The aim of the current study was to implement immunoinformatics approaches to infer sequence- and structure-based molecular mimicry between viral and human proteomic datasets. The protein sequences of all the so far known human-infecting viruses were obtained from the VIPR database, and complete human proteome data were retrieved from the NCBI repository. Based on a predefined, stringent threshold of comparative sequence analyses, 24 viral proteins were identified with significant sequence similarity to human proteins. PathDIP identified the enrichment of these homologou","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-08T03:11:57.207Z","creation":"2025-02-19T03:23:18.919Z"},"accession":"S-EPMC9696880","cross_references":{"pubmed":["36422613"],"doi":["10.3390/pathogens11111362"]}}