biostudies-literatureKappel SSInnovation Fund Denmark4756https://www.ebi.ac.uk/biostudies/studies/S-EPMC9696900biostudies-literatureUnknown14(22)<h4>Background</h4>Human milk does not meet the nutritional needs to support optimal growth of very preterm infants during the first weeks of life. Nutrient fortifiers are therefore added to human milk, though these products are suspected to increase gut dysmotility. The objective was to evaluate whether fortification with bovine colostrum (BC) improves bowel habits compared to a conventional fortifier (CF) in very preterm infants.<h4>Methods</h4>In an unblinded, randomized study, 242 preterm infants (26-31 weeks of gestation) were randomized to receive BC (BC, Biofiber Damino, Gesten, Denmark) or CF (FM85 PreNAN, Nestlé, Vevey, Switzerland) as a fortifier. Stools (Amsterdam Stool Scale), bowel gas restlessness, stomach appearance score, volume, and frequency of gastric residuals were recoNutrientsA Randomized, Controlled Study to Investigate How Bovine Colostrum Fortification of Human Milk Affects Bowel Habits in Preterm Infants (FortiColos Study).PMC96969006150-00004BFriborg CZachariassen GAunsholt LSangild PTSoernsen LJAhnfeldt AMMoller SKappel SSJohannsdottir VBak LBfalseA Randomized, Controlled Study to Investigate How Bovine Colostrum Fortification of Human Milk Affects Bowel Habits in Preterm Infants (FortiColos Study).<h4>Background</h4>Human milk does not meet the nutritional needs to support optimal growth of very preterm infants during the first weeks of life. Nutrient fortifiers are therefore added to human milk, though these products are suspected to increase gut dysmotility. The objective was to evaluate whether fortification with bovine colostrum (BC) improves bowel habits compared to a conventional fortifier (CF) in very preterm infants.<h4>Methods</h4>In an unblinded, randomized study, 242 preterm infants (26-31 weeks of gestation) were randomized to receive BC (BC, Biofiber Damino, Gesten, Denmark) or CF (FM85 PreNAN, Nestlé, Vevey, Switzerland) as a fortifier. Stools (Amsterdam Stool Scale), bowel gas restlessness, stomach appearance score, volume, and frequency of gastric residuals were reco2022-01-01T00:00:00Z2022 Nov2025-04-19T00:37:02.031Z2025-04-07T11:44:49.865ZS-EPMC96969003643244410.3390/nu14224756