biostudies-literatureCervilla-Martinez JFNational Institute of Health14018https://www.ebi.ac.uk/biostudies/studies/S-EPMC9696982biostudies-literatureUnknown23(22)The relationship between Parkinson's disease (PD), the second-most common neurodegenerative disease after Alzheimer's disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this study, to better understand the role of protein palmitoylation in PD and the pathways altered in this disease, we analyzed the differential palmitoyl proteome (palmitome) in the cerebral cortex of PD patients compared to controls (<i>n</i> = 4 per group). Data-mining of the cortical palmitome from PD patients and controls allowed us to: (i) detect a set of 150 proteins with altered palmitoylation in PD subjects in comparison with controls; (ii) describe the biological pathways and targets predicted to be altered by these palmitoylation changes; and (iii) depict the overlap International journal of molecular sciencesAltered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson's Disease.PMC9696982R21NS085358Rodriguez-Gotor JJWypijewski KJFontan-Lozano ASantamaria EWang TCervilla-Martinez JFFuller WMejias RfalseAltered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson's Disease.The relationship between Parkinson's disease (PD), the second-most common neurodegenerative disease after Alzheimer's disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this study, to better understand the role of protein palmitoylation in PD and the pathways altered in this disease, we analyzed the differential palmitoyl proteome (palmitome) in the cerebral cortex of PD patients compared to controls (<i>n</i> = 4 per group). Data-mining of the cortical palmitome from PD patients and controls allowed us to: (i) detect a set of 150 proteins with altered palmitoylation in PD subjects in comparison with controls; (ii) describe the biological pathways and targets predicted to be altered by these palmitoylation changes; and (iii) depict the overlap 2022-01-01T00:00:00Z2022 Nov2025-04-04T13:28:15.749Z2025-04-04T13:28:15.749ZS-EPMC96969823643049710.3390/ijms232214018