biostudies-literatureUnknown14(22)Yoshida ATo elucidate the age-related sex difference in glucose tolerance, we conducted 75 g oral glucose tolerance tests in 1156 participants. Participants were divided into four groups, namely, young (22-29) males, young females, middle-aged (>50) males, and middle-aged females. According to the Japanese Clinical Practice Guideline for Diabetes 2019, the prevalence of normal glucose tolerance (NGT) was significantly lower in middle-aged than in young participants. The prevalence of high-normal fasting plasma glucose (FPG) was higher, and NGT was lower in young males (high-normal FPG 15.2%, NGT 82.0%) than young females (high-FPG 3.9%, NGT 94.3%). Combined glucose intolerance (CGI) was higher and NGT was lower in middle-aged males (CGI 10.2%, NGT 25.2%) than in middle-aged females (CGI 3.3%, NGNutrients4868https://www.ebi.ac.uk/biostudies/studies/S-EPMC9698682biostudies-literatureAge-Related Sex Differences in Glucose Tolerance by 75 g Oral Glucose Tolerance Test in Japanese.PMC9698682Shoho YTsunekawa KYoshida AKimura TMurakami MAoki TAraki OOgiwara TYanagawa YfalseAge-Related Sex Differences in Glucose Tolerance by 75 g Oral Glucose Tolerance Test in Japanese.To elucidate the age-related sex difference in glucose tolerance, we conducted 75 g oral glucose tolerance tests in 1156 participants. Participants were divided into four groups, namely, young (22-29) males, young females, middle-aged (>50) males, and middle-aged females. According to the Japanese Clinical Practice Guideline for Diabetes 2019, the prevalence of normal glucose tolerance (NGT) was significantly lower in middle-aged than in young participants. The prevalence of high-normal fasting plasma glucose (FPG) was higher, and NGT was lower in young males (high-normal FPG 15.2%, NGT 82.0%) than young females (high-FPG 3.9%, NGT 94.3%). Combined glucose intolerance (CGI) was higher and NGT was lower in middle-aged males (CGI 10.2%, NGT 25.2%) than in middle-aged females (CGI 3.3%, NG2022-01-01T00:00:00Z2022 Nov2025-04-04T13:28:02.467Z2025-04-04T13:28:02.467ZS-EPMC96986823643255410.3390/nu14224868