{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Van der Weijst L"],"funding":["NCI NIH HHS"],"pagination":["228-241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9698940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["166"],"pubmed_abstract":["<h4>Objectives</h4>Radiotherapy-induced toxicity may negatively impact health-related quality of life (HRQoL). This report investigates the impact of curative-intent radiotherapy on HRQoL and toxicity in early stage and locally-advanced non-small cell lung cancer patients treated with radiotherapy or chemo-radiotherapy enrolled in the observational prospective REQUITE study.<h4>Materials and methods</h4>HRQoL was assessed using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire up to 2 years post radiotherapy. Eleven toxicities were scored by clinicians using the Common Terminology Criteria for Adverse Events (CTCAE) version 4. Toxicity scores were calculated by subtracting baseline values. Mixed model analyses were applied to determine statistical signifi"],"journal":["Lung cancer (Amsterdam, Netherlands)"],"pubmed_title":["Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)."],"pmcid":["PMC9698940"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["Molla M","Berkovic P","Taboada-Lorenzo B","Symonds P","Rimner A","Lambrecht M","Rosenstein BS","Ennis D","Seibold P","Gutierrez-Enriquez S","Bultijnck R","Rancati T","Chang-Claude J","Defraene G","Franceschini M","Veldeman L","De Ruysscher D","Higginson DS","Sperk E","Veldwijk MR","Briers E","Sangalli C","Herskind C","Surmont V","Johnson K","Kerns SL","Elliott RM","Vega A","Salem A","REQUITE Consortium","Van der Weijst L","Summersgill H","Demontois S","Boisselier P","Ward T","Calvo-Crespo P","Faivre-Finn C","West CML","Choudhury A","Stobart H","Talbot CJ","Azria D","Aguado-Barrera ME","Lievens Y","Ramos M","Sosa-Fajardo P","Dunning AM","Valdagni R","Webb A"],"additional_accession":[]},"is_claimable":false,"name":"Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study).","description":"<h4>Objectives</h4>Radiotherapy-induced toxicity may negatively impact health-related quality of life (HRQoL). This report investigates the impact of curative-intent radiotherapy on HRQoL and toxicity in early stage and locally-advanced non-small cell lung cancer patients treated with radiotherapy or chemo-radiotherapy enrolled in the observational prospective REQUITE study.<h4>Materials and methods</h4>HRQoL was assessed using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire up to 2 years post radiotherapy. Eleven toxicities were scored by clinicians using the Common Terminology Criteria for Adverse Events (CTCAE) version 4. Toxicity scores were calculated by subtracting baseline values. Mixed model analyses were applied to determine statistical signifi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-05-18T13:45:43.998Z","creation":"2024-10-18T23:45:39.184Z"},"accession":"S-EPMC9698940","cross_references":{"pubmed":["35334417"],"doi":["10.1016/j.lungcan.2022.03.010"]}}