biostudies-literatureAlcala-Santiago AConsejería de Salud de la Junta de Andalucía and co-funded by the European Regional Development Fund(ERDF-FEDER)Consejería de Salud de la Junta de Andalucía14256https://www.ebi.ac.uk/biostudies/studies/S-EPMC9699081biostudies-literatureUnknown23(22)Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values < 0.05 as statistically significant) of the pathways, and gene-disease associationsInternational journal of molecular sciencesVitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations.PMC9699081PECOVID-0200-2020Gil AJimenez-Sousa MASanchez MJMolina-Montes EAlcala-Santiago ARodriguez-Barranco MRava MfalseVitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations.Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values < 0.05 as statistically significant) of the pathways, and gene-disease associations2022-01-01T00:00:00Z2022 Nov2026-04-08T15:52:31.011Z2024-10-18T09:21:49.358ZS-EPMC96990813643072910.3390/ijms232214256