biostudies-literatureDantas ACSImprovement of Higher Education PersonnelCAPES-PRINT/UFBACoordenação de Aperfeicoamento de Pessoal de Nível SuperiorCRP—ICGEB RESEARCH GRANT 2020 ProjectInternational Centre for Genetic Engineering and BiotechnologyFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro2424https://www.ebi.ac.uk/biostudies/studies/S-EPMC9699198biostudies-literatureUnknown14(11)Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for causing Coronavirus Disease-2019 (COVID-19), a heterogeneous clinical condition that manifests varying symptom severity according to the demographic profile of the studied population. While many studies have focused on the spread of COVID-19 in large urban centers in Brazil, few have evaluated medium or small cities in the Northeast region. The aims of this study were: (i) to identify risk factors for mortality from SARS-CoV-2 infection, (ii) to evaluate the gene expression patterns of key immune response pathways using nasopharyngeal swabs of COVID-19 patients, and (iii) to identify the circulating SARS-CoV-2 variants in the residents of a medium-sized city in Northeast Brazil. A total of 783 patients infectedVirusesRetrospective Analysis of the SARS-CoV-2 Infection Profile in COVID-19 Positive Patients in Vitoria da Conquista, Northeast Brazil.PMC9699198CAPES-PRINT/UFBACAPES—EDITAL CAPES 11/2020 EPIDEMIAS, PROJETO: 88887.506992/2020-00-AUXPE: 630/2020, Code 001EDITAL CAPES 11/2020 EPIDEMIAS, PROJETO: 88887.506992/ 2020-00-AUXPE: 510 630/2020GRANT 2020 Project CRP/BRA20-03, Contract CRP/20/03E26/202.665/2019 (247400)Code 001(E-514 26/202.248/2018(238504); E26/202.665/2019 (247400)CAPES-PRINT/UFBA (Tema: Inovações em saúde e ambiente como estra-511 tégias para a redução das desigualdades sociais e melhoria da qualidade de vida)CRP/BRA20-03E-514 26/202.248/2018 (238504)Giovanetti MAlcantara LCJMoreira PMBMarques LMDantas ACSFonseca Vde Oliveira MGGNascimento ALPOliveira CNTSantos LAGomes CPCucco MSGuimaraes AMSInfante PDBTimenetsky JOliveira HBMPereira TTSAlves DLCampos GBde Medeiros DSBittencourt RSCaitite RJASilva LSCMistro Sde Oliveira SHPde Melo FFAmorim ATFritsch HMBarreto FKMarinho FAGCfalseRetrospective Analysis of the SARS-CoV-2 Infection Profile in COVID-19 Positive Patients in Vitoria da Conquista, Northeast Brazil.Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for causing Coronavirus Disease-2019 (COVID-19), a heterogeneous clinical condition that manifests varying symptom severity according to the demographic profile of the studied population. While many studies have focused on the spread of COVID-19 in large urban centers in Brazil, few have evaluated medium or small cities in the Northeast region. The aims of this study were: (i) to identify risk factors for mortality from SARS-CoV-2 infection, (ii) to evaluate the gene expression patterns of key immune response pathways using nasopharyngeal swabs of COVID-19 patients, and (iii) to identify the circulating SARS-CoV-2 variants in the residents of a medium-sized city in Northeast Brazil. A total of 783 patients infected2022-01-01T00:00:00Z2022 Oct2025-04-19T16:09:47.525Z2024-11-08T10:55:13.77ZS-EPMC96991983636652110.3390/v14112424