{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morel JL"],"funding":["Centre National de la Recherche Scientifique","Region Nouvelle-Aquitaine","Centre National d’Etudes spatiales"],"pagination":["780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9699600"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from <i>Leuirus quinquestratus quinquestratus</i> venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which selectively inhibited the chloride conductance without effects on either calcium signaling or calcium and potassium currents expressed in this cell type. The synthetic peptide had the same affin"],"journal":["Toxins"],"pubmed_title":["Characterization of a Family of Scorpion Toxins Modulating Ca<sup>2+</sup>-Activated Cl<sup>-</sup> Current in Vascular Myocytes."],"pmcid":["PMC9699600"],"funding_grant_id":["4500072566"],"pubmed_authors":["Sautiere P","Hugues M","Drobecq H","Morel JL","Lippens G","Mokrzycki N"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of a Family of Scorpion Toxins Modulating Ca<sup>2+</sup>-Activated Cl<sup>-</sup> Current in Vascular Myocytes.","description":"The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from <i>Leuirus quinquestratus quinquestratus</i> venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which selectively inhibited the chloride conductance without effects on either calcium signaling or calcium and potassium currents expressed in this cell type. The synthetic peptide had the same affin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-04-08T03:24:29.391Z","creation":"2025-04-05T23:15:32.34Z"},"accession":"S-EPMC9699600","cross_references":{"pubmed":["36356031"],"doi":["10.3390/toxins14110780"]}}