biostudies-literatureUnknown62(1)Liu HOral cancer is one of the highly malignant tumors with poor prognosis. The pathogenic mechanisms of oral cancer have remained to be fully elucidated and this brings significant challenges to the treatment. RNA modification is a common intracellular chemical modification that has been related to various pathological processes, such as blood diseases, immune system diseases and cancer. As the most common and abundant RNA modification in eukaryotic mRNA, N⁶‑methyladenosine (m⁶A) modification has a crucial role in several cancers, including oral cancer. m⁶A modification directly affects gene expression levels and regulates various physiological and pathological processes. It has been demonstrated that m⁶A modification may affect the proliferation, miInternational journal of oncology5https://www.ebi.ac.uk/biostudies/studies/S-EPMC9699723biostudies-literatureRoles of m⁶A modification in oral cancer (Review).PMC9699723Liu HXue TYang ZKan SHao MWang DGao YWang YLiu WfalseRoles of m⁶A modification in oral cancer (Review).Oral cancer is one of the highly malignant tumors with poor prognosis. The pathogenic mechanisms of oral cancer have remained to be fully elucidated and this brings significant challenges to the treatment. RNA modification is a common intracellular chemical modification that has been related to various pathological processes, such as blood diseases, immune system diseases and cancer. As the most common and abundant RNA modification in eukaryotic mRNA, N⁶‑methyladenosine (m⁶A) modification has a crucial role in several cancers, including oral cancer. m⁶A modification directly affects gene expression levels and regulates various physiological and pathological processes. It has been demonstrated that m⁶A modification may affect the proliferation, mi2023-01-01T00:00:00Z2023 Jan2025-04-19T15:39:37.723Z2025-04-19T15:39:37.723ZS-EPMC96997233638264210.3892/ijo.2022.5453